HitPredict

Interactor 1: ANK1 (P16157)
Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)
Gene: ANK1

Interactor 2: OBSCN (Q5VST9)
Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)
Gene: OBSCN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.908

Property	Details
Experiments	12631729, 16962094, 12527750, 22573887
Identification Methods	two hybrid, pull down, unspecified method, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank~I-set, Ank~Pkinase, Ank_2~fn3, Ank_2~I-set, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030018 - Z disc GO:0031430 - M band GO:0042383 - sarcolemma
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1881 Hs			1 7968
+	Hs
		965118 ANK2_HUMAN (808-1879): 2.96e-13: 78: 10.00		OBSCN_HUMAN (1-7968): 0: 5809: 100.00
+	Hs
		556704 ANK1_HUMAN (1-1881): 0: 1738: 100.00		Q4KMX9_HUMAN (1069-1159): 4.11e-36: 139: 79.12
+	Hs
		556716 ANK1_HUMAN (1-1881): 0: 1738: 100.00		TITIN_HUMAN (7238-7621): 5.23e-10: 69.5: 12.50
+	Hs
		166985 ANR28_HUMAN (243-938): 5.56e-164: 531: 25.37		TITIN_HUMAN (7238-7621): 5.23e-10: 69.5: 12.50
+	Hs
		279899 ANFY1_HUMAN (339-1001): 1.04e-74: 275: 18.41		TRIO_HUMAN (5562-5999): 1.29e-22: 111: 24.73
+	Hs
		862028 ANK2_HUMAN (808-1879): 2.96e-13: 78: 10.00		DAPK1_HUMAN (7677-7924): 2.14e-26: 123: 30.42
+	Mm
		57869 ANK2_MOUSE (811-1870): 2.99e-11: 71.4: 12.55		KALRN_MOUSE (1070-1294): 1.08e-11: 74.9: 10.04