HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6)
Gene: PSMA1

Interactor 2: PSA2 (P25787)
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2)
Gene: PSMA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.985

The method score is based on:

Property Details
Experiments 32296183, 33961781, 12376572, 14733938, 19193609, 15887188, 26186194, 28514442, 29568061, 35271311, 35235311, 37217651, 21988832, unassigned1655, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, biochemical, proximity labelling technology, cross-linking study, pull down, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid and 1 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 4 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 263
Hs

1 234
+ Ce
+ Zm
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+ Dm
+ Dm
+ Hs
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+ Dm
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Last updated: 11Aug2025