HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 540
+	Hs
		276999 PGFRA_HUMAN (1-1089): 0: 817: 100.00		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		276989 PGFRB_HUMAN (29-1089): 0: 650: 43.33		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		159875 PGFRA_HUMAN (1-1089): 0: 817: 100.00		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		557088 PGFRA_HUMAN (1-1089): 0: 817: 100.00		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		159856 PGFRB_HUMAN (29-1089): 0: 650: 43.33		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		452385 PGFRB_HUMAN (29-1089): 0: 650: 43.33		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		609455 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		STAM1_HUMAN (1-518): 1.32e-126: 382: 100.00
+	Mm
		292679 KIT_MOUSE (18-994): 0: 571: 33.43		GRAP2_MOUSE (213-264): 1.05e-13: 73.9: 55.77
+	Mm
		403541 KIT_MOUSE (18-994): 0: 571: 33.43		GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90
+	Hs
		277004 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		275165 KIT_HUMAN (18-978): 0: 559: 33.64		GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69
+	Hs
		499253 KIT_HUMAN (18-978): 0: 559: 33.64		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		738192 FLT3_HUMAN (4-979): 1e-158: 498: 27.84		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Ce
		666210 EGL15_CAEEL (5-1072): 3.56e-155: 490: 16.61		SEM5_CAEEL (204-264): 7.13e-12: 67: 44.26
+	Hs
		924527 MERTK_HUMAN (121-1073): 2.64e-131: 425: 17.11		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		159889 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		609244 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Rn
		1144355 NTRK2_RAT (87-776): 3.54e-53: 202: 14.10		HGS_RAT (84-540): 8.24e-15: 79.4: 13.31
+	Mm
		546322 NTRK2_MOUSE (53-776): 3.36e-53: 202: 13.62		HGS_MOUSE (84-540): 2.18e-13: 75.2: 13.12
+	Hs
		729636 VGFR2_HUMAN (7-588): 8.16e-51: 198: 17.81		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90