Protein: ADA15
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)

Gene: ADA15, ADAM15
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q13444

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001669 - acrosomal vesicle
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0002418 - immune response to tumor cell
GO:0004222 - metalloendopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1105827

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

12

High-throughput

0.811

High

987612

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.707

High

557284

SRC
Proto-oncogene tyrosine-protein kinase Src

4

20

Small-scale

0.702

High

1105817

SNX33
Sorting nexin-33

4

20

Small-scale

0.696

High

567851

PRG2
Bone marrow proteoglycan

1

13

High-throughput

0.691

High

1105818

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.691

High

1105838

SNX9
Sorting nexin-9

3

20

Small-scale

0.687

High

473413

HCK
Tyrosine-protein kinase HCK

3

20

Small-scale

0.680

High

440062

LCK
Tyrosine-protein kinase Lck

3

20

Small-scale

0.676

High

698634

CALX
Calnexin

3

17

High-throughput

0.650

High

184290

NPHP1
Nephrocystin-1

2

2

Small-scale

0.646

High

440542

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.636

High

593986

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.634

High

1105835

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

2

20

Small-scale

0.631

High

463505

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.629

High

1105805

SPD2A
SH3 and PX domain-containing protein 2A

3

19

Small-scale

0.622

High

424031

ITB3
Integrin beta-3

1

17

Small-scale

0.618

High

1105829

FBX6
F-box only protein 6

2

12

High-throughput

0.584

High

50290

ODAM
Odontogenic ameloblast-associated protein

2

0

High-throughput

0.580

High

1105824

SH3G2
Endophilin-A1

1

20

Small-scale

0.573

High

320240

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.561

High

463083

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.561

High

1054105

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.536

High

1105821

OSTF1
Osteoclast-stimulating factor 1

1

14

Small-scale

0.536

High

341304

ECEL1
Endothelin-converting enzyme-like 1

1

3

High-throughput

0.536

High

548012

PSPC
Surfactant protein C

1

4

High-throughput

0.536

High

570666

EDN3
Endothelin-3

1

2

High-throughput

0.536

High

1105808

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.536

High

1105809

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

1105834

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

4

Small-scale

0.526

High

1036842

SP4
Transcription factor Sp4

1

1

High-throughput

0.523

High

1105797

FHL3
Four and a half LIM domains protein 3

1

4

High-throughput

0.523

High

188879

TMPS2
Transmembrane protease serine 2

1

19

High-throughput

0.515

High

703576

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.515

High

1105798

PTK6
Protein-tyrosine kinase 6

1

20

Small-scale

0.515

High

1105830

TMPS4
Transmembrane protease serine 4

1

19

High-throughput

0.515

High

1105826

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.513

High

1105799

ARHG7
Rho guanine nucleotide exchange factor 7

1

7

Small-scale

0.512

High

1105800

ARHG6
Rho guanine nucleotide exchange factor 6

1

6

Small-scale

0.512

High

1105816

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

Small-scale

0.512

High

1105837

SHLB1
Endophilin-B1

1

17

Small-scale

0.512

High

572823

NCF1
Neutrophil cytosol factor 1

1

20

Small-scale

0.501

High

699735

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

Small-scale

0.501

High

840879

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.501

High

1065080

ITK
Tyrosine-protein kinase ITK/TSK

1

20

Small-scale

0.501

High

1105803

ITSN1
Intersectin-1

1

11

Small-scale

0.501

High

1105802

PCH2
Pachytene checkpoint protein 2 homolog

1

2

High-throughput

0.494

High

191439

SIA8E
Alpha-2,8-sialyltransferase 8E

1

2

High-throughput

0.489

High

1105828

SDF2L
Stromal cell-derived factor 2-like protein 1

1

7

High-throughput

0.489

High

218150

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

362279

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.479

High

370193

CYTN
Cystatin-SN

1

5

Small-scale

0.479

High

473699

ITA5
Integrin alpha-5

1

4

Small-scale

0.479

High

691734

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

692952

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

774766

TIMP3
Metalloproteinase inhibitor 3

1

6

Small-scale

0.479

High

1105796

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1105801

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

1105810

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

1105813

TM11B
Transmembrane protease serine 11B

1

18

High-throughput

0.479

High

1105820

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1105825

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.479

High

1105831

T106B
Transmembrane protein 106B

1

7

High-throughput

0.479

High

1105814

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

1105806

SNX30
Sorting nexin-30

1

19

Small-scale

0.457

High

1105832

RIM3A
RIMS-binding protein 3A

1

12

Small-scale

0.457

High

166296

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

4

High-throughput

0.445

High

1010913

BAT1
b(0,+)-type amino acid transporter 1

1

4

High-throughput

0.445

High

1060349

SLC31
Amino acid transporter heavy chain SLC3A1

1

3

High-throughput

0.445

High

1105804

S39AC
Zinc transporter ZIP12

1

10

High-throughput

0.445

High

1105807

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1105811

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1105833

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

1

High-throughput

0.445

High

1105836

XCT
Cystine/glutamate transporter

1

4

High-throughput

0.445

High

1099665

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

4

Small-scale

0.437

High

1105812

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

Small-scale

0.437

High

552955

PIP
Prolactin-inducible protein

1

0

High-throughput

0.426

High

844768

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

1105823

SPAG5
Sperm-associated antigen 5

1

4

Small-scale

0.417

High

170749

CLGN
Calmegin

1

17

High-throughput

0.407

High

1105819

S39A7
Zinc transporter SLC39A7

1

10

High-throughput

0.407

High

927278

ATX1
Ataxin-1

2

0

High-throughput

0.316

High

789107

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.299

High

1105815

BANP
Protein BANP

1

0

High-throughput

0.299

High

1105822

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.299

High


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Last updated: 11Aug2025