Protein: ADA22
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)

Gene: ADA22, ADAM22
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q9P0K1

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0007155 - cell adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1122362

SCRIB
Protein scribble homolog

2

9

Small-scale

0.768

High

351807

LGI1
Leucine-rich glioma-inactivated protein 1

2

2

Small-scale

0.705

High

990806

1433Z
14-3-3 protein zeta/delta

2

5

Small-scale

0.589

High

581340

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.541

High

1116076

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.541

High

699211

CALX
Calnexin

1

16

High-throughput

0.536

High

1180976

HFE
Hereditary hemochromatosis protein

1

15

High-throughput

0.536

High

1308305

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

4

High-throughput

0.536

High

1453789

PCDAB
Protocadherin alpha-11

1

1

High-throughput

0.536

High

1322574

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.513

High

1399068

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

691489

1433T
14-3-3 protein theta

1

5

Small-scale

0.506

High

730299

1433B
14-3-3 protein beta/alpha

1

5

Small-scale

0.506

High

423351

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

473479

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.501

High

1091585

DLG1
Disks large homolog 1

1

10

High-throughput

0.501

High

885908

KC1E
Casein kinase I isoform epsilon

1

4

High-throughput

0.489

High

997542

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.489

High

1090376

EPS8
Epidermal growth factor receptor kinase substrate 8

1

17

High-throughput

0.481

High

218887

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

376034

RASK
GTPase KRas

1

7

High-throughput

0.479

High

463807

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.479

High

901630

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

1006114

DLG4
Disks large homolog 4

1

11

Small-scale

0.479

High

1049846

1433F
14-3-3 protein eta

1

5

Small-scale

0.479

High

972075

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

227183

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

7

Small-scale

0.439

High

106767

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

405352

OAT
Ornithine aminotransferase, mitochondrial

1

1

High-throughput

0.437

High

956521

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.437

High

1395303

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

519426

MYB
Transcriptional activator Myb

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025