HitPredict

Interactor 1: PP2BB (P16298)
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta)
Gene: PPP3CB

Interactor 2: RCAN1 (P53805)
Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)
Gene: RCAN1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	27880917, 28514442, 33961781, 35914814
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0031987 - locomotion involved in locomotory behavior GO:0033173 - calcineurin-NFAT signaling cascade GO:0048741 - skeletal muscle fiber development
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 524 Hs			1 252
+	Hs
		865104 PP2BA_HUMAN (13-523): 0: 843: 83.20		RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00
+	Hs
		819141 PP2BC_HUMAN (20-516): 0: 810: 82.33		RCAN1_HUMAN (1-252): 1.54e-148: 416: 100.00
+	Hs
		557546 PP2BB_HUMAN (22-524): 0: 870: 100.00		RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20
+	Hs
		557578 PP2BB_HUMAN (22-524): 0: 870: 100.00		RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00
+	Hs
		994080 PP2BA_HUMAN (13-523): 0: 843: 83.20		RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20
+	Hs
		994121 PP2BA_HUMAN (13-523): 0: 843: 83.20		RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00
+	Hs
		819151 PP2BC_HUMAN (20-516): 0: 810: 82.33		RCAN2_HUMAN (52-248): 1.9e-99: 290: 60.20
+	Hs
		819181 PP2BC_HUMAN (20-516): 0: 810: 82.33		RCAN3_HUMAN (57-252): 9.15e-98: 287: 59.00
+	Ce
		865127 PP2B_CAEEL (23-503): 0: 747: 74.95		RCANL_CAEEL (62-234): 1.65e-87: 260: 42.61
+	Dm
		1375383 PP2B3_DROME (11-508): 0: 780: 76.59		SRA_DROME (55-245): 1.33e-71: 222: 39.38
+	Dm
		1099957 PP2B2_DROME (22-520): 0: 773: 76.49		SRA_DROME (55-245): 1.33e-71: 222: 39.38