HitPredict

Interactor 1: ESM8 (P13098)
Enhancer of split m8 protein (E(spl)m8)
Gene: E(spl)m8-HLH

Interactor 2: ESMB (Q01069)
Enhancer of split mbeta protein (E(spl)mbeta) (HLH-mbeta) (Split locus enhancer protein mA)
Gene: E(spl)mbeta-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	9371806
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0043565 - sequence-specific DNA binding GO:0050767 - regulation of neurogenesis
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 179 Dm			1 195
+	Dm
		1028552 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESMB_DROME (1-195): 7.46e-69: 210: 100.00
+	Dm
		560209 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESMC_DROME (6-195): 3.26e-52: 168: 50.00
+	Dm
		560199 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESM8_DROME (7-195): 1.4e-51: 165: 35.45
+	Dm
		560175 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESM7_DROME (1-195): 1.94e-48: 157: 44.55
+	Dm
		1028553 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESMC_DROME (6-195): 3.26e-52: 168: 50.00
+	Dm
		560210 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESMD_DROME (7-195): 6.25e-46: 151: 38.95
+	Dm
		560178 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESM7_DROME (1-195): 1.94e-48: 157: 44.55
+	Dm
		560179 ESM7_DROME (3-179): 9e-52: 165: 40.86		ESMC_DROME (6-195): 3.26e-52: 168: 50.00
+	Dm
		1028539 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESM3_DROME (5-195): 1.09e-46: 154: 40.81
+	Dm
		560161 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESM5_DROME (8-195): 9.86e-42: 140: 31.58
+	Dm
		1028554 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESMD_DROME (7-195): 6.25e-46: 151: 38.95
+	Dm
		560200 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		HAIR_DROME (4-179): 3.15e-37: 133: 27.84
+	Dm
		560165 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESM5_DROME (8-195): 9.86e-42: 140: 31.58
+	Dm
		560180 ESM7_DROME (3-179): 9e-52: 165: 40.86		ESMD_DROME (7-195): 6.25e-46: 151: 38.95
+	Dm
		560160 ESM7_DROME (3-179): 9e-52: 165: 40.86		ESM5_DROME (8-195): 9.86e-42: 140: 31.58
+	Dm
		560166 ESMC_DROME (1-179): 4.13e-51: 164: 35.00		ESM5_DROME (8-195): 9.86e-42: 140: 31.58