HitPredict

Interactor 1: ESM8 (P13098)
Enhancer of split m8 protein (E(spl)m8)
Gene: E(spl)m8-HLH

Interactor 2: ESMC (Q01070)
Enhancer of split mgamma protein (E(spl)mgamma) (Split locus enhancer protein mB)
Gene: E(spl)mgamma-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.768

Property	Details
Experiments	9371806, 22949507
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0043565 - sequence-specific DNA binding GO:0050767 - regulation of neurogenesis
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 179 Dm			1 205
+	Dm
		1028553 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESMC_DROME (1-205): 2.83e-68: 209: 100.00
+	Dm
		560179 ESM7_DROME (3-179): 9e-52: 165: 40.86		ESMC_DROME (1-205): 2.83e-68: 209: 100.00
+	Dm
		560208 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESMB_DROME (8-205): 1.18e-54: 174: 50.00
+	Dm
		560210 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESMD_DROME (1-205): 9.74e-52: 166: 36.59
+	Dm
		560175 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESM7_DROME (8-205): 3.08e-51: 165: 47.48
+	Dm
		1028552 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESMB_DROME (8-205): 1.18e-54: 174: 50.00
+	Dm
		560199 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESM8_DROME (6-205): 5.27e-48: 157: 34.48
+	Dm
		1028554 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESMD_DROME (1-205): 9.74e-52: 166: 36.59
+	Dm
		560178 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESM7_DROME (8-205): 3.08e-51: 165: 47.48
+	Dm
		560161 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		ESM5_DROME (2-205): 3.11e-45: 149: 32.35
+	Dm
		1028539 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESM3_DROME (8-205): 7.81e-49: 160: 40.09
+	Dm
		560180 ESM7_DROME (3-179): 9e-52: 165: 40.86		ESMD_DROME (1-205): 9.74e-52: 166: 36.59
+	Dm
		560200 ESM8_DROME (1-179): 1.12e-61: 190: 100.00		HAIR_DROME (13-201): 6.7e-40: 140: 29.10
+	Dm
		560165 ESMB_DROME (3-179): 5.07e-56: 176: 35.26		ESM5_DROME (2-205): 3.11e-45: 149: 32.35
+	Dm
		560160 ESM7_DROME (3-179): 9e-52: 165: 40.86		ESM5_DROME (2-205): 3.11e-45: 149: 32.35
+	Dm
		560166 ESMC_DROME (1-179): 4.13e-51: 164: 35.00		ESM5_DROME (2-205): 3.11e-45: 149: 32.35