HitPredict

Interactor 1: ESM7 (P13097)
Enhancer of split m7 protein (E(spl)m7)
Gene: E(spl)m7-HLH

Interactor 2: ESM8 (P13098)
Enhancer of split m8 protein (E(spl)m8)
Gene: E(spl)m8-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.723

Property	Details
Experiments	9371806, unassigned4
Identification Methods	two hybrid, experimental interaction detection
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0043565 - sequence-specific DNA binding GO:0050767 - regulation of neurogenesis
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 186 Dm			1 179
+	Dm
		560178 ESM7_DROME (1-186): 1.5e-64: 198: 100.00		ESMB_DROME (3-179): 5.07e-56: 176: 35.26
+	Dm
		560179 ESM7_DROME (1-186): 1.5e-64: 198: 100.00		ESMC_DROME (1-179): 4.13e-51: 164: 35.00
+	Dm
		560208 ESMB_DROME (1-186): 8e-53: 168: 44.06		ESM8_DROME (1-179): 1.12e-61: 190: 100.00
+	Dm
		560209 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		ESM8_DROME (1-179): 1.12e-61: 190: 100.00
+	Dm
		560160 ESM7_DROME (1-186): 1.5e-64: 198: 100.00		ESM5_DROME (2-179): 1.53e-46: 152: 60.00
+	Dm
		560180 ESM7_DROME (1-186): 1.5e-64: 198: 100.00		ESMD_DROME (3-179): 6.74e-46: 150: 32.42
+	Dm
		1028552 ESMB_DROME (1-186): 8e-53: 168: 44.06		ESMB_DROME (3-179): 5.07e-56: 176: 35.26
+	Dm
		1028553 ESMB_DROME (1-186): 8e-53: 168: 44.06		ESMC_DROME (1-179): 4.13e-51: 164: 35.00
+	Dm
		1028558 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		ESMC_DROME (1-179): 4.13e-51: 164: 35.00
+	Dm
		1028561 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		DPN_DROME (4-172): 1.9e-46: 159: 24.16
+	Dm
		560165 ESMB_DROME (1-186): 8e-53: 168: 44.06		ESM5_DROME (2-179): 1.53e-46: 152: 60.00
+	Dm
		1028554 ESMB_DROME (1-186): 8e-53: 168: 44.06		ESMD_DROME (3-179): 6.74e-46: 150: 32.42
+	Dm
		1028564 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		HEY_DROME (2-173): 5.12e-44: 152: 19.10
+	Dm
		560166 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		ESM5_DROME (2-179): 1.53e-46: 152: 60.00
+	Dm
		1028539 ESMB_DROME (1-186): 8e-53: 168: 44.06		ESM3_DROME (3-179): 3.87e-44: 147: 24.78
+	Dm
		1028559 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		ESMD_DROME (3-179): 6.74e-46: 150: 32.42
+	Dm
		1028540 ESMC_DROME (6-186): 2.49e-51: 165: 47.48		ESM3_DROME (3-179): 3.87e-44: 147: 24.78