HitPredict

Interactor 1: YBOX3 (P16989)
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)
Gene: YBX3

Interactor 2: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 784
+	Hs
		931215 YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89		E4F1_HUMAN (1-784): 0: 590: 100.00
+	Hs
		931362 YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89		ZN184_HUMAN (2-272): 1.02e-108: 350: 17.50
+	Hs
		1305555 YBOX2_HUMAN (58-366): 4.54e-50: 173: 42.54		ZN184_HUMAN (2-272): 1.02e-108: 350: 17.50
+	Hs
		931344 YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89		ZN514_HUMAN (192-268): 7.29e-12: 70.1: 38.96
+	Hs
		931435 YBOX1_HUMAN (58-372): 1.88e-52: 178: 45.89		PRDM9_HUMAN (192-271): 5.87e-09: 61.6: 36.25
+	Hs
		1350393 YBOX2_HUMAN (58-366): 4.54e-50: 173: 42.54		ZN624_HUMAN (2-55): 1.11e-09: 64: 12.96
+	Hs
		563313 LN28A_HUMAN (82-256): 3.86e-42: 148: 25.82		ZNF16_HUMAN (621-770): 1.71e-13: 76.3: 7.33