Protein: TGFR1
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

Gene: TGFR1, TGFBR1
Organism: Homo sapiens
Interactions: 141
UniProt ID: P36897

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001701 - in utero embryonic development
GO:0001822 - kidney development
GO:0001824 - blastocyst development
GO:0001837 - epithelial to mesenchymal transition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738506

TGFR2
TGF-beta receptor type-2

13

20

Small-scale

0.977

High

738520

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

6

7

Small-scale

0.944

High

351287

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

6

20

Small-scale

0.935

High

495651

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

3

20

Small-scale

0.858

High

431603

HS90A
Heat shock protein HSP 90-alpha

3

15

Small-scale

0.857

High

201246

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

14

Small-scale

0.827

High

738505

ACVL1
Serine/threonine-protein kinase receptor R3

2

19

Small-scale

0.776

High

167338

SMAD7
Mothers against decapentaplegic homolog 7

19

20

Small-scale

0.763

High

738516

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.754

High

738543

BMPR2
Bone morphogenetic protein receptor type-2

2

20

Small-scale

0.754

High

738548

SMAD2
Mothers against decapentaplegic homolog 2

10

20

Small-scale

0.753

High

738578

SMUF2
E3 ubiquitin-protein ligase SMURF2

8

19

Small-scale

0.741

High

571090

EGLN
Endoglin

6

12

Small-scale

0.738

High

738538

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.724

High

738597

TRAF6
TNF receptor-associated factor 6

5

6

Small-scale

0.720

High

738526

SMAD3
Mothers against decapentaplegic homolog 3

5

20

Small-scale

0.714

High

488145

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.691

High

570307

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

2

High-throughput

0.691

High

665161

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.691

High

738542

AVR2B
Activin receptor type-2B

1

20

High-throughput

0.691

High

738561

ACV1C
Activin receptor type-1C

1

19

High-throughput

0.691

High

738599

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.691

High

738588

DP13A
DCC-interacting protein 13-alpha

1

0

Small-scale

0.687

High

654126

CALX
Calnexin

4

4

High-throughput

0.683

High

738525

FKB1B
Peptidyl-prolyl cis-trans isomerase FKBP1B

1

7

Small-scale

0.680

High

738596

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

4

14

Small-scale

0.676

High

738586

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

15

Small-scale

0.665

High

738533

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

13

High-throughput

0.646

High

738579

SMUF1
E3 ubiquitin-protein ligase SMURF1

3

19

Small-scale

0.640

High

738595

STRAP
Serine-threonine kinase receptor-associated protein

3

2

Small-scale

0.640

High

738536

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

14

Small-scale

0.634

High

130773

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

4

Small-scale

0.624

High

155290

NRP1
Neuropilin-1

2

3

Small-scale

0.624

High

320502

OXSR1
Serine/threonine-protein kinase OSR1

1

13

Small-scale

0.618

High

434147

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.618

High

436183

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

564434

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

738504

TGFR1
TGF-beta receptor type-1

1

18

Small-scale

0.618

High

738508

NOTC1
Neurogenic locus notch homolog protein 1

1

2

Small-scale

0.618

High

738515

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

738517

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

738518

TGFB2
Transforming growth factor beta-2 proprotein

1

20

Small-scale

0.618

High

738519

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

738521

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

738527

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

738541

SQSTM
Sequestosome-1

1

4

Small-scale

0.618

High

738545

ARHG6
Rho guanine nucleotide exchange factor 6

1

5

Small-scale

0.618

High

738547

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

Small-scale

0.618

High

738549

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.618

High

738553

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

738565

OSTF1
Osteoclast-stimulating factor 1

1

10

High-throughput

0.618

High

738567

HAVR1
Hepatitis A virus cellular receptor 1

1

3

Small-scale

0.618

High

738572

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

4

Small-scale

0.618

High

738577

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

738580

PAR6A
Partitioning defective 6 homolog alpha

1

4

Small-scale

0.618

High

738583

RASF1
Ras association domain-containing protein 1

1

1

Small-scale

0.618

High

555092

CD44
CD44 antigen

2

2

Small-scale

0.595

High

738532

ACVR1
Activin receptor type-1

1

19

High-throughput

0.590

High

556690

ANK1
Ankyrin-1

1

0

Small-scale

0.586

High

206941

SMAD6
Mothers against decapentaplegic homolog 6

2

20

Small-scale

0.584

High

655243

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

7

Small-scale

0.584

High

738531

CAV1
Caveolin-1

2

6

Small-scale

0.584

High

738563

TGFA1
Transforming growth factor-beta receptor-associated protein 1

2

3

Small-scale

0.584

High

239826

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

9

High-throughput

0.575

High

500738

CLUS
Clusterin

1

1

Small-scale

0.573

High

738546

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.573

High

738571

RANB9
Ran-binding protein 9

1

1

Small-scale

0.573

High

271043

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

11

Small-scale

0.561

High

521228

SKI
Ski oncogene

1

1

Small-scale

0.561

High

738513

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

Small-scale

0.561

High

738537

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.561

High

738568

OTUB1
Ubiquitin thioesterase OTUB1

1

4

Small-scale

0.561

High

738510

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

1

Small-scale

0.549

High

506901

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.547

High

362647

A2GL
Leucine-rich alpha-2-glycoprotein

1

20

Small-scale

0.536

High

318356

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

530237

ICAM2
Intercellular adhesion molecule 2

1

1

High-throughput

0.536

High

738514

EVA1C
Protein eva-1 homolog C

1

2

High-throughput

0.536

High

738528

DAB2
Disabled homolog 2

1

2

Small-scale

0.536

High

738535

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

5

High-throughput

0.536

High

738539

KLRD1
Natural killer cells antigen CD94

1

5

High-throughput

0.536

High

738551

CC50B
Cell cycle control protein 50B

1

3

High-throughput

0.536

High

738552

I20RB
Interleukin-20 receptor subunit beta

1

7

High-throughput

0.536

High

738564

CLC2B
C-type lectin domain family 2 member B

1

5

High-throughput

0.536

High

738591

CLC4A
C-type lectin domain family 4 member A

1

1

High-throughput

0.536

High

177832

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

738523

1433Z
14-3-3 protein zeta/delta

1

5

Small-scale

0.515

High

738582

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.515

High

738587

NLGN3
Neuroligin-3

1

2

High-throughput

0.515

High

430687

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

702331

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

738573

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.513

High

738594

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

738598

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

738524

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

4

Small-scale

0.512

High

738581

TMM9B
Transmembrane protein 9B

1

3

High-throughput

0.489

High

738589

MYT1L
Myelin transcription factor 1-like protein

1

0

Small-scale

0.480

High

129227

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

12

Small-scale

0.479

High

167855

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

205117

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

259561

HMMR
Hyaluronan mediated motility receptor

1

2

Small-scale

0.479

High

301364

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

11

Small-scale

0.479

High

443047

ITA5
Integrin alpha-5

1

4

Small-scale

0.479

High

521335

SKIL
Ski-like protein

1

1

Small-scale

0.479

High

714116

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

738509

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

19

Small-scale

0.479

High

738512

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

14

Small-scale

0.479

High

738522

AP2B1
AP-2 complex subunit beta

1

7

Small-scale

0.479

High

738529

XIAP
E3 ubiquitin-protein ligase XIAP

1

7

Small-scale

0.479

High

738530

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.479

High

738534

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

738540

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.479

High

738550

OCLN
Occludin

1

2

Small-scale

0.479

High

738554

ZFY16
Zinc finger FYVE domain-containing protein 16

1

2

Small-scale

0.479

High

738555

KCNKI
Potassium channel subfamily K member 18

1

5

Small-scale

0.479

High

738556

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

738557

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.479

High

738558

GOLI
E3 ubiquitin-protein ligase RNF130

1

12

High-throughput

0.479

High

738560

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.479

High

738562

DLG5
Disks large homolog 5

1

1

Small-scale

0.479

High

738566

SH3K1
SH3 domain-containing kinase-binding protein 1

1

6

Small-scale

0.479

High

738569

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

19

Small-scale

0.479

High

738570

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

738575

TRAF4
TNF receptor-associated factor 4

1

6

Small-scale

0.479

High

738576

TOLIP
Toll-interacting protein

1

1

Small-scale

0.479

High

738590

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

738592

SNX6
Sorting nexin-6

1

8

Small-scale

0.479

High

738593

RNF11
RING finger protein 11

1

14

Small-scale

0.479

High

738574

MYOC
Myocilin

1

0

Small-scale

0.460

High

451203

TPM1
Tropomyosin alpha-1 chain

1

0

Small-scale

0.458

High

648672

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

727958

SOX11
Transcription factor SOX-11

1

0

Small-scale

0.458

High

738507

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

738511

PSN1
Presenilin-1

1

0

Small-scale

0.458

High

738585

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

Small-scale

0.458

High

738544

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

738584

FBX34
F-box only protein 34

1

1

Small-scale

0.437

High

209215

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

514349

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

738559

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024