HitPredict

Interactor 1: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Interactor 2: FAB1 (P34756)
1-phosphatidylinositol 3-phosphate 5-kinase FAB1 (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (Formation of aploid and binucleate cells protein 1) (Styryl dye vacuolar localization protein 7) (Type III PIP kinase) (PIPkin-III)
Gene: FAB1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28637746
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016310 - phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 305 Sc			1 2278
+	Sc
		339563 CDK1_YEAST (6-299): 5.63e-128: 368: 52.17		FAB1_YEAST (1-2278): 0: 2030: 100.00
+	Hs
		625228 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		TCPG_HUMAN (656-1193): 5.56e-166: 523: 14.88
+	Hs
		625220 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		TCPE_HUMAN (647-1174): 1.32e-164: 519: 12.72
+	Hs
		414817 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		TCPE_HUMAN (647-1174): 1.32e-164: 519: 12.72
+	Hs
		573132 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		TCPA_HUMAN (661-1182): 3.83e-154: 491: 11.50
+	Hs
		826623 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		TCPG_HUMAN (656-1193): 5.56e-166: 523: 14.88
+	Hs
		625579 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		TCPH_HUMAN (661-1192): 1.64e-153: 489: 12.32
+	Hs
		821173 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		TCPE_HUMAN (647-1174): 1.32e-164: 519: 12.72
+	Hs
		414725 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		TCPA_HUMAN (661-1182): 3.83e-154: 491: 11.50
+	Hs
		415042 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		TCPH_HUMAN (661-1192): 1.64e-153: 489: 12.32
+	Hs
		573225 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		TCPA_HUMAN (661-1182): 3.83e-154: 491: 11.50
+	Hs
		960322 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		TCPH_HUMAN (661-1192): 1.64e-153: 489: 12.32
+	Hs
		573231 CDK18_HUMAN (7-297): 6.83e-98: 298: 54.98		TCPA_HUMAN (661-1182): 3.83e-154: 491: 11.50
+	Hs
		625246 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		TCPD_HUMAN (685-1181): 4.03e-112: 370: 15.50
+	Hs
		414827 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		TCPD_HUMAN (685-1181): 4.03e-112: 370: 15.50
+	Hs
		843162 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		TCPD_HUMAN (685-1181): 4.03e-112: 370: 15.50
+	Sc
		339390 CDK1_YEAST (6-299): 5.63e-128: 368: 52.17		TCPA_YEAST (674-1178): 1.07e-112: 373: 13.88
+	Hs
		414854 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		PI42B_HUMAN (1988-2208): 3.85e-54: 198: 24.11
+	Hs
		415003 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		PI42C_HUMAN (1988-2205): 2.71e-53: 195: 24.55
+	Hs
		960350 CDK5_HUMAN (4-303): 1.72e-131: 377: 54.31		FYV1_HUMAN (100-563): 5.88e-42: 172: 17.98