HitPredict

Interactor 1: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 672 Hs			1 245
+	Hs
		566348 KPCA_HUMAN (1-672): 0: 794: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		397155 KPCG_HUMAN (1-670): 0: 706: 68.94		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		566346 KPCA_HUMAN (1-672): 0: 794: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		408587 KPCB_HUMAN (1-664): 0: 749: 78.89		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		909458 KPCE_HUMAN (8-664): 0: 635: 44.61		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		646812 KPCE_HUMAN (8-664): 0: 635: 44.61		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		926942 KPCE_HUMAN (8-664): 0: 635: 44.61		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		683276 KPCE_HUMAN (8-664): 0: 635: 44.61		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		397138 KPCG_HUMAN (1-670): 0: 706: 68.94		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		397154 KPCG_HUMAN (1-670): 0: 706: 68.94		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Mm
		554936 KPCE_MOUSE (8-664): 0: 637: 44.76		1433B_MOUSE (1-242): 2.84e-124: 354: 80.99
+	Hs
		683974 KPCE_HUMAN (8-664): 0: 635: 44.61		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904456 KPCE_HUMAN (8-664): 0: 635: 44.61		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		681770 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		681776 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		116972 SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		116995 SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		681682 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		681766 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		683287 KPCD_HUMAN (9-167): 3.67e-57: 207: 39.65		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82