Protein: K2C1B
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)

Gene: K2C1B, KRT77
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q7Z794

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0030280 - structural constituent of skin epidermis
GO:0031424 - keratinization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618063

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.845

High

1146008

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.845

High

475615

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

300586

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

1277567

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

1280847

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

1047441

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.665

High

300398

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.621

High

385135

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.621

High

476348

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.621

High

1127657

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.621

High

1277672

K1C25
Keratin, type I cytoskeletal 25

1

20

High-throughput

0.621

High

341801

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.618

High

385298

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

436919

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

437246

K2C8
Keratin, type II cytoskeletal 8

1

19

High-throughput

0.618

High

474785

VIME
Vimentin

1

20

High-throughput

0.618

High

475769

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

566414

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

606130

DESM
Desmin

1

20

High-throughput

0.618

High

833305

PERI
Peripherin

1

20

High-throughput

0.618

High

1280864

KRT84
Keratin, type II cuticular Hb4

1

19

High-throughput

0.618

High

990420

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.584

High

563997

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.536

High

1280848

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1280851

DCNL1
DCN1-like protein 1

1

3

High-throughput

0.536

High

1136459

FL2D
Pre-mRNA-splicing regulator WTAP

1

7

High-throughput

0.489

High

1280861

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

13

High-throughput

0.489

High

141549

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

302568

RNF8
E3 ubiquitin-protein ligase RNF8

1

14

High-throughput

0.479

High

396420

ESR1
Estrogen receptor

1

13

High-throughput

0.479

High

401062

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

414114

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

605735

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

7

Small-scale

0.479

High

711375

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

730007

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730720

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

855669

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

966542

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971713

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.479

High

1049496

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1104605

IKZF1
DNA-binding protein Ikaros

1

5

High-throughput

0.479

High

1194191

LARP7
La-related protein 7

1

10

High-throughput

0.479

High

1246861

RICTR
Rapamycin-insensitive companion of mTOR

1

6

High-throughput

0.479

High

1280849

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

7

Small-scale

0.479

High

1280850

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.479

High

1280859

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1280860

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

1280862

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

10

High-throughput

0.479

High

1280863

ANLN
Anillin

1

11

High-throughput

0.479

High

1280865

RNF12
E3 ubiquitin-protein ligase RLIM

1

16

High-throughput

0.479

High

1280867

HDAC6
Protein deacetylase HDAC6

1

11

High-throughput

0.479

High

1280868

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1280869

IKZF3
Zinc finger protein Aiolos

1

4

High-throughput

0.479

High

1280842

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1280853

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

342938

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.445

High

765665

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

862264

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.445

High

952223

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

1063800

LG3BP
Galectin-3-binding protein

1

8

High-throughput

0.445

High

1280844

KIBRA
Protein KIBRA

1

18

High-throughput

0.445

High

1280856

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

1280858

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

244263

NUAK1
NUAK family SNF1-like kinase 1

1

2

High-throughput

0.437

High

293936

CD123
Translation initiation factor eIF2 assembly protein

1

9

High-throughput

0.437

High

324963

HEXI1
Protein HEXIM1

1

17

High-throughput

0.437

High

353422

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.437

High

372438

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.437

High

406336

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.437

High

1088420

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.437

High

1118078

DX39B
Spliceosome RNA helicase DDX39B

1

20

High-throughput

0.437

High

1132791

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.437

High

1135900

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

High-throughput

0.437

High

1155508

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.437

High

1258052

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

2

High-throughput

0.437

High

1271710

MEPCE
7SK snRNA methylphosphate capping enzyme

1

10

High-throughput

0.437

High

1280846

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

6

High-throughput

0.437

High

1280855

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

1280857

DDX24
ATP-dependent RNA helicase DDX24

1

19

High-throughput

0.437

High

1280854

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.426

High

1074

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

1119185

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.407

High

1280843

SULF2
Extracellular sulfatase Sulf-2

1

10

High-throughput

0.407

High

1280845

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

1280852

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

1280866

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.278

Low


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Last updated: 11Aug2025