HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: LAMC2 (Q13753)
Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma)
Gene: LAMC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0008201 - heparin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 222 Hs			1 1193
+	Hs
		1117045 PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30		LAMC2_HUMAN (1-1193): 0: 590: 100.00
+	Hs
		455971 ASGR2_HUMAN (5-221): 4.05e-40: 141: 16.30		LAMC2_HUMAN (1-1193): 0: 590: 100.00
+	Hs
		568017 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		NOTC3_HUMAN (282-743): 1.9e-32: 140: 14.34
+	Hs
		158528 NCAN_HUMAN (16-221): 7.19e-45: 161: 16.80		TENA_HUMAN (2-301): 6.54e-36: 151: 15.50
+	Hs
		567854 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		LAMB3_HUMAN (8-188): 2.07e-30: 132: 31.94
+	Hs
		567836 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		NOTC2_HUMAN (277-743): 3.21e-28: 126: 13.55
+	Hs
		1117031 PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30		LAMB3_HUMAN (8-188): 2.07e-30: 132: 31.94
+	Hs
		1047786 PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30		NOTC2_HUMAN (277-743): 3.21e-28: 126: 13.55
+	Hs
		446107 FCER2_HUMAN (5-220): 1.84e-50: 168: 20.08		NOTC2_HUMAN (277-743): 3.21e-28: 126: 13.55
+	Hs
		567812 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		NOTC1_HUMAN (328-743): 1.31e-24: 114: 13.60
+	Hs
		183290 PGCB_HUMAN (10-221): 6.77e-53: 184: 17.20		LAMA5_HUMAN (1-126): 8.17e-11: 69.2: 17.69
+	Hs
		937430 PGCB_HUMAN (10-221): 6.77e-53: 184: 17.20		LAMB2_HUMAN (99-284): 5.5e-10: 66.1: 14.77
+	Hs
		183222 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		LAMA5_HUMAN (1-126): 8.17e-11: 69.2: 17.69
+	Hs
		535811 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		LAMC1_HUMAN (69-285): 6.19e-10: 66.1: 17.99
+	Hs
		567823 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		LAMB2_HUMAN (99-284): 5.5e-10: 66.1: 14.77
+	Hs
		567830 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		PGBM_HUMAN (71-154): 8.4e-10: 65.7: 16.67
+	Hs
		568030 PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00		LAMC3_HUMAN (175-430): 1.44e-09: 65: 10.55
+	Hs
		937454 PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30		LAMB2_HUMAN (99-284): 5.5e-10: 66.1: 14.77
+	Hs
		462883 COL12_HUMAN (90-221): 1.39e-39: 146: 23.36		LAMB1_HUMAN (69-337): 9.67e-11: 68.8: 13.19
+	Hs
		535847 COL12_HUMAN (90-221): 1.39e-39: 146: 23.36		LAMC1_HUMAN (69-285): 6.19e-10: 66.1: 17.99