Protein: PRG3
Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH)

Gene: PRG3
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9Y2Y8

Gene Ontology (top 5):
GO:0001694 - histamine biosynthetic process
GO:0005576 - extracellular region
GO:0006955 - immune response
GO:0017148 - negative regulation of translation
GO:0019370 - leukotriene biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317595

SLIT2
Slit homolog 2 protein

2

7

High-throughput

0.811

High

551830

CO6A1

2

6

High-throughput

0.776

High

551903

CO6A2

2

7

High-throughput

0.776

High

1047786

NOTC2
Neurogenic locus notch homolog protein 2

1

9

High-throughput

0.691

High

756595

GALNS
N-acetylgalactosamine-6-sulfatase

3

5

High-throughput

0.662

High

1294398

FRAS1
Extracellular matrix organizing protein FRAS1

3

13

High-throughput

0.662

High

1390374

I17RA
Interleukin-17 receptor A

3

1

High-throughput

0.662

High

1087086

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.656

High

772351

FBN2
Fibrillin-2 [Cleaved into: Placensin]

2

17

High-throughput

0.628

High

1307957

ARMC8
Armadillo repeat-containing protein 8

2

1

High-throughput

0.628

High

1369117

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

12

High-throughput

0.628

High

376565

LDLR
Low-density lipoprotein receptor

3

6

High-throughput

0.604

High

1250538

RBP10
Ran-binding protein 10

3

6

High-throughput

0.604

High

1272761

MAEA
E3 ubiquitin-protein transferase MAEA

3

11

High-throughput

0.604

High

1461469

MKLN1
Muskelin

3

1

High-throughput

0.604

High

287632

LRP6
Low-density lipoprotein receptor-related protein 6

2

6

High-throughput

0.601

High

1117031

LAMB3
Laminin subunit beta-3

2

14

High-throughput

0.601

High

671878

ZA2G
Zinc-alpha-2-glycoprotein

1

6

High-throughput

0.575

High

1022506

IDD
Integral membrane protein DGCR2/IDD

1

11

High-throughput

0.575

High

1132153

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

19

High-throughput

0.575

High

282911

Z324A
Zinc finger protein 324A

2

1

High-throughput

0.574

High

931316

AT12A
Potassium-transporting ATPase alpha chain 2

2

1

High-throughput

0.574

High

1108765

TBB3
Tubulin beta-3 chain

2

2

High-throughput

0.574

High

1193219

OFUT4
GDP-fucose protein O-fucosyltransferase 4

2

1

High-throughput

0.574

High

1208467

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

2

3

High-throughput

0.574

High

1309325

GID4
Glucose-induced degradation protein 4 homolog

2

1

High-throughput

0.574

High

1333666

PGLT1
Protein O-glucosyltransferase 1

2

4

High-throughput

0.574

High

1388518

ZMY19
Zinc finger MYND domain-containing protein 19

2

1

High-throughput

0.574

High

1391449

RMD5B
E3 ubiquitin-protein transferase RMND5B

2

9

High-throughput

0.574

High

1402350

RANB9
Ran-binding protein 9

2

6

High-throughput

0.574

High

1435678

WDR26
WD repeat-containing protein 26

2

4

High-throughput

0.574

High

1436208

RMD5A
E3 ubiquitin-protein transferase RMND5A

2

9

High-throughput

0.574

High

1451502

GID8
Glucose-induced degradation protein 8 homolog

2

11

High-throughput

0.574

High

611759

BMP7
Bone morphogenetic protein 7

1

5

High-throughput

0.536

High

876291

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

1

High-throughput

0.536

High

997197

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.536

High

1248936

ARSK
Arylsulfatase K

1

5

High-throughput

0.536

High

1333900

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

5

High-throughput

0.536

High

1408518

GDF15
Growth/differentiation factor 15

1

7

High-throughput

0.536

High

1461193

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

10

High-throughput

0.536

High

86055

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

3

High-throughput

0.514

High

1402433

HPLN3
Hyaluronan and proteoglycan link protein 3

1

8

High-throughput

0.514

High

251130

B4GT3
Beta-1,4-galactosyltransferase 3

1

1

High-throughput

0.489

High

612128

ITB5
Integrin beta-5

1

5

High-throughput

0.489

High

932398

ANAG
Alpha-N-acetylglucosaminidase

1

1

High-throughput

0.489

High

1225419

METRL
Meteorin-like protein

1

3

High-throughput

0.489

High

1248348

PLGT2
Protein O-glucosyltransferase 2

1

4

High-throughput

0.489

High

1372157

EXT2
Exostosin-2

1

2

High-throughput

0.489

High

327124

NXPH4
Neurexophilin-4

1

2

High-throughput

0.445

High

366224

HPT
Haptoglobin

1

5

High-throughput

0.445

High

369415

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.445

High

390973

TRFE
Serotransferrin

1

2

High-throughput

0.445

High

391109

TRFL
Lactotransferrin

1

2

High-throughput

0.445

High

452119

PROS
Vitamin K-dependent protein S

1

15

High-throughput

0.445

High

519682

LYAG
Lysosomal alpha-glucosidase

1

1

High-throughput

0.445

High

572702

NID1
Nidogen-1

1

5

High-throughput

0.445

High

683765

PTX3
Pentraxin-related protein PTX3

1

2

High-throughput

0.445

High

937454

LAMB2
Laminin subunit beta-2

1

12

High-throughput

0.445

High

945950

LOXL3
Lysyl oxidase homolog 3

1

8

High-throughput

0.445

High

946273

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

10

High-throughput

0.445

High

963249

LYSC
Lysozyme C

1

1

High-throughput

0.445

High

1117045

LAMC2
Laminin subunit gamma-2

1

20

High-throughput

0.445

High

1162162

MA2A1
Alpha-mannosidase 2

1

4

High-throughput

0.445

High

1286313

GALT7
N-acetylgalactosaminyltransferase 7

1

5

High-throughput

0.445

High

1337772

LFNG
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

1

2

High-throughput

0.445

High

1351351

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.445

High

1356097

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

8

High-throughput

0.445

High

1445831

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.445

High

1491004

LOXL2
Lysyl oxidase homolog 2

1

8

High-throughput

0.445

High

378729

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.426

High

553101

PIP
Prolactin-inducible protein

1

0

High-throughput

0.426

High

593718

BGAL
Beta-galactosidase

1

0

High-throughput

0.426

High

1251525

CD109
CD109 antigen

1

0

High-throughput

0.426

High

1387181

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.426

High

1429196

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.426

High

161109

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

14

High-throughput

0.407

High

300066

CBPD
Carboxypeptidase D

1

1

High-throughput

0.407

High

351768

SG1D2
Secretoglobin family 1D member 2

1

1

High-throughput

0.407

High

843064

PCP
Lysosomal Pro-X carboxypeptidase

1

1

High-throughput

0.407

High

876745

HSP13
Heat shock 70 kDa protein 13

1

5

High-throughput

0.407

High

1006235

CNTP1
Contactin-associated protein 1

1

12

High-throughput

0.407

High

1281707

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

20

High-throughput

0.407

High

1336112

KREM2
Kremen protein 2

1

12

High-throughput

0.407

High

1430862

SIL1
Nucleotide exchange factor SIL1

1

1

High-throughput

0.407

High

1452797

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

2

High-throughput

0.407

High

1460513

PLXA1
Plexin-A1

1

7

High-throughput

0.407

High

1217404

AB17B
Alpha/beta hydrolase domain-containing protein 17B

2

0

High-throughput

0.328

High

1454657

TXD16
Thioredoxin domain-containing protein 16

2

0

High-throughput

0.328

High

183873

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.279

Low

244513

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.279

Low

690062

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

1157318

PROL4
Proline-rich protein 4

1

0

High-throughput

0.232

Low

1230817

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.232

Low

1248871

CF089
Bombesin receptor-activated protein C6orf89

1

0

High-throughput

0.232

Low

1277975

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.232

Low

1458597

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025