HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27114451
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Hs			1 409
+	Hs
		872248 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00
+	Rn
		906973 PRS4_RAT (32-433): 5.45e-136: 399: 43.60		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Rn
		1117332 PRS6A_RAT (1-439): 1.39e-135: 398: 99.32		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Rn
		1104198 Q32PW9_RAT (44-432): 5.05e-135: 394: 39.33		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Hs
		572906 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		872133 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Dm
		1359291 Q9V405_DROME (6-438): 4.77e-130: 383: 37.64		Q9V3W9_DROME (1-408): 5.38e-89: 277: 36.75
+	Hs
		573110 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Hs
		906946 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Hs
		573100 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Hs
		906941 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Hs
		573087 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71
+	Hs
		906929 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71
+	Dm
		820528 PRS4_DROME (5-433): 2.8e-136: 400: 42.49		Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08
+	Dm
		1359420 Q9V405_DROME (6-438): 4.77e-130: 383: 37.64		Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08
+	Mm
		476744 PRS4_MOUSE (32-433): 5.45e-136: 399: 43.60		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Mm
		292076 PRS6A_MOUSE (1-439): 2.99e-135: 397: 99.32		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		906808 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		RL40_HUMAN (1-91): 3.57e-33: 122: 28.57
+	Dm
		820508 PRS4_DROME (5-433): 2.8e-136: 400: 42.49		Q9VCD5_DROME (1-238): 9.23e-20: 90.7: 19.92
+	Hs
		572921 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67