HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	30737378, 33591636
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 488
+	Hs
		764934 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		577744 PLAK_HUMAN (1-745): 0: 550: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		764729 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		142595 IMA3_HUMAN (228-670): 8.24e-65: 226: 16.01		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		138736 IMA4_HUMAN (228-670): 1.86e-63: 222: 15.79		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		911027 IMA1_HUMAN (270-664): 9.2e-48: 179: 14.32		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		577916 PLAK_HUMAN (1-745): 0: 550: 100.00		HDAC6_HUMAN (11-363): 6.97e-102: 332: 24.04
+	Hs
		253668 IMA7_HUMAN (266-685): 6.6e-45: 171: 15.27		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		142545 IMA3_HUMAN (228-670): 8.24e-65: 226: 16.01		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		138683 IMA4_HUMAN (228-670): 1.86e-63: 222: 15.79		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		765082 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		HDAC6_HUMAN (11-363): 6.97e-102: 332: 24.04
+	Hs
		910883 IMA1_HUMAN (270-664): 9.2e-48: 179: 14.32		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		253623 IMA7_HUMAN (266-685): 6.6e-45: 171: 15.27		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		254237 CTND1_HUMAN (203-728): 3.16e-90: 305: 16.25		HDAC6_HUMAN (11-363): 6.97e-102: 332: 24.04
+	Mm
		204701 IMA4_MOUSE (228-670): 6.51e-64: 224: 15.57		HDAC4_MOUSE (1-377): 6.15e-133: 412: 23.89
+	Hs
		764912 CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38		HDAC7_HUMAN (29-280): 1.97e-23: 106: 26.37