HitPredict

Interactor 1: MEGF6 (O75095)
Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3)
Gene: MEGF6

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1541 Hs			1 1731
+	Hs
		1316311 NOTC3_HUMAN (7-802): 3.68e-52: 205: 16.77		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1296145 MEG10_HUMAN (10-684): 6.23e-51: 199: 20.34		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1231801 LTBP4_HUMAN (186-1498): 4.18e-37: 155: 12.84		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316313 JAG2_HUMAN (1118-1541): 6.71e-29: 128: 17.23		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		804330 NOTC1_HUMAN (13-549): 1.51e-26: 121: 13.48		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		61630 MEG11_HUMAN (20-369): 1.41e-15: 84.7: 14.52		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		980523 NOTC2_HUMAN (1341-1541): 4.51e-12: 73.5: 20.69		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		167042 NOTC3_HUMAN (7-802): 3.68e-52: 205: 16.77		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Dm
		65546 NOTCH_DROME (20-1133): 1.92e-86: 316: 17.33		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Dm
		422915 NOTCH_DROME (20-1133): 1.92e-86: 316: 17.33		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Hs
		166914 NOTC2_HUMAN (1341-1541): 4.51e-12: 73.5: 20.69		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		1237561 NOTC3_HUMAN (7-802): 3.68e-52: 205: 16.77		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		804293 NOTC1_HUMAN (13-549): 1.51e-26: 121: 13.48		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Mm
		1193399 JAG2_MOUSE (1118-1541): 9.22e-28: 124: 17.67		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Hs
		1231741 SORL_HUMAN (1067-1538): 1.44e-25: 117: 12.65		AN36B_HUMAN (67-198): 2.66e-16: 87.4: 18.18
+	Hs
		980449 NOTC2_HUMAN (1341-1541): 4.51e-12: 73.5: 20.69		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Ce
		81043 CED1_CAEEL (21-468): 4.93e-18: 92.7: 14.74		SHANK_CAEEL (1659-1728): 9.7e-09: 62.8: 42.86
+	Hs
		944122 JAG1_HUMAN (16-286): 3.61e-10: 67.3: 13.79		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Mm
		1193398 JAG1_MOUSE (16-286): 7.24e-09: 62.7: 13.10		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Dm
		113976 M9PB30_DROME (28-582): 5.47e-12: 73.5: 12.93		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73