HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	9398617, 12598525
Identification Methods	pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0043536 - positive regulation of blood vessel endothelial cell migration GO:0045766 - positive regulation of angiogenesis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1290 Hs			1 1356
+	Mm
		729415 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		VGFR2_MOUSE (1-1356): 0: 981: 85.79
+	Dm
		112240 Q9VXH3_DROME (15-1215): 0: 945: 40.88		M9MRE1_DROME (31-1354): 0: 608: 21.17
+	Hs
		557029 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71
+	Hs
		452348 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		499230 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		580923 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR2_HUMAN (1-231): 3.47e-24: 112: 9.57
+	Hs
		572583 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VGFR1_HUMAN (1-131): 5.1e-20: 99.3: 13.38
+	Mm
		404014 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		PGFRB_MOUSE (1-516): 1.05e-22: 107: 13.40
+	Hs
		580927 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90
+	Hs
		507843 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Mm
		729715 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		VGFR1_MOUSE (1-131): 3.12e-19: 96.6: 13.38
+	Hs
		580926 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Rn
		499160 PLCG1_RAT (1-1290): 0: 1299: 96.90		FGFR1_RAT (1-169): 2.32e-16: 87: 13.02
+	Hs
		499228 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Mm
		452188 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		CSF1R_MOUSE (458-821): 1.83e-18: 93.9: 12.14
+	Hs
		507835 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		499290 PLCE1_HUMAN (157-454): 2.17e-75: 278: 35.69		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		609614 PLCL2_HUMAN (840-1240): 4.61e-92: 324: 29.23		FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90
+	Hs
		1254602 PLCL2_HUMAN (840-1240): 4.61e-92: 324: 29.23		DSCL1_HUMAN (368-772): 1.52e-16: 88.1: 11.92