HitPredict

Interactor 1: PGAM2 (P15259)
Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M)
Gene: PGAM2

Interactor 2: PGAM4 (Q8N0Y7)
Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4)
Gene: PGAM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	26186194, 28514442, 33961781, 35575683, 38334954
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	His_Phos_1~His_Phos_1
Common GO terms	GO:0004082 - bisphosphoglycerate mutase activity GO:0004619 - phosphoglycerate mutase activity GO:0006096 - glycolytic process GO:0016787 - hydrolase activity GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 253 Hs			1 254
+	Hs
		582067 PGAM2_HUMAN (1-253): 8.37e-126: 359: 100.00		PGAM2_HUMAN (1-253): 1.11e-120: 345: 77.87
+	Hs
		582069 PGAM2_HUMAN (1-253): 8.37e-126: 359: 100.00		PGAM1_HUMAN (1-254): 7.31e-118: 339: 95.67
+	Hs
		616201 PGAM1_HUMAN (1-253): 1.89e-119: 342: 81.03		PGAM4_HUMAN (1-254): 4.77e-111: 321: 100.00
+	Hs
		459830 PGAM2_HUMAN (1-253): 8.37e-126: 359: 100.00		PMGE_HUMAN (1-254): 7.28e-104: 303: 51.95
+	Dm
		1468182 Q9VGB6_DROME (3-253): 2.49e-116: 336: 68.25		Q9VAN7_DROME (3-253): 1.53e-107: 312: 66.27
+	Hs
		459831 PGAM1_HUMAN (1-253): 1.89e-119: 342: 81.03		PMGE_HUMAN (1-254): 7.28e-104: 303: 51.95
+	Hs
		1322377 PGAM4_HUMAN (1-253): 3.08e-111: 322: 77.87		PGAM4_HUMAN (1-254): 4.77e-111: 321: 100.00
+	Hs
		459844 PGAM4_HUMAN (1-253): 3.08e-111: 322: 77.87		PMGE_HUMAN (1-254): 7.28e-104: 303: 51.95
+	Sc
		368527 PMG1_YEAST (4-252): 1.05e-99: 292: 51.81		PMG1_YEAST (4-252): 5.64e-95: 280: 48.19
+	Rn
		464233 F261_RAT (1-239): 8.04e-63: 205: 20.08		F261_RAT (1-239): 4.18e-60: 198: 20.08
+	Hs
		591921 F261_HUMAN (1-239): 1.08e-62: 205: 20.50		F261_HUMAN (1-245): 5.45e-60: 198: 19.59
+	Hs
		591931 F261_HUMAN (1-239): 1.08e-62: 205: 20.50		F264_HUMAN (1-239): 3.91e-60: 198: 20.92
+	Hs
		591930 F261_HUMAN (1-239): 1.08e-62: 205: 20.50		F263_HUMAN (1-240): 4.77e-57: 191: 19.58
+	Hs
		257051 F264_HUMAN (1-239): 1.37e-62: 204: 20.50		F262_HUMAN (1-239): 4.21e-56: 188: 18.83