Protein: F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

Gene: F263, PFKFB3
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q16875

Gene Ontology (top 5):
GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1164293

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

3

15

Small-scale

0.861

High

257050

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

2

15

High-throughput

0.811

High

591930

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

2

15

High-throughput

0.783

High

1164292

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

14

Small-scale

0.647

High

729873

1433B
14-3-3 protein beta/alpha

3

19

High-throughput

0.643

High

363351

EGFR
Epidermal growth factor receptor

3

3

High-throughput

0.633

High

139545

PESC
Pescadillo homolog

2

1

High-throughput

0.628

High

691051

1433T
14-3-3 protein theta

2

19

High-throughput

0.601

High

966370

1433G
14-3-3 protein gamma

2

19

High-throughput

0.601

High

990278

1433Z
14-3-3 protein zeta/delta

2

19

High-throughput

0.601

High

1049332

1433F
14-3-3 protein eta

2

19

High-throughput

0.601

High

273062

CLU
Clustered mitochondria protein homolog

2

1

High-throughput

0.574

High

541515

FGFR1
Fibroblast growth factor receptor 1

2

5

High-throughput

0.571

High

717312

PEBP1
Phosphatidylethanolamine-binding protein 1

2

3

High-throughput

0.571

High

1164301

SH3K1
SH3 domain-containing kinase-binding protein 1

2

3

High-throughput

0.571

High

1144528

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

1145861

RBP1
RalA-binding protein 1

2

0

High-throughput

0.547

High

764798

CTNB1
Catenin beta-1

1

0

Small-scale

0.537

High

529897

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

732610

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

882502

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

909018

NEK4
Serine/threonine-protein kinase Nek4

1

11

High-throughput

0.536

High

964626

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.536

High

1112858

CUL2
Cullin-2

1

3

High-throughput

0.515

High

1164311

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1032321

OTUD4
OTU domain-containing protein 4

1

3

Small-scale

0.501

High

772356

HXK4
Hexokinase-4

1

3

Small-scale

0.481

High

241831

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

247936

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

293764

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

319804

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.479

High

349105

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

396219

ESR1
Estrogen receptor

1

4

High-throughput

0.479

High

807445

IF4A3
Eukaryotic initiation factor 4A-III

1

3

High-throughput

0.479

High

926666

HIRA
Protein HIRA

1

1

Small-scale

0.479

High

957405

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

961044

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

970590

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

998372

H31
Histone H3.1

1

1

High-throughput

0.479

High

1164295

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1164299

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

5

Small-scale

0.479

High

1164300

ASB12
Ankyrin repeat and SOCS box protein 12

1

3

High-throughput

0.479

High

1164302

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

Small-scale

0.479

High

1164303

SNX27
Sorting nexin-27

1

3

High-throughput

0.479

High

1164304

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

1164305

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.479

High

1164306

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1164307

TXNIP
Thioredoxin-interacting protein

1

7

Small-scale

0.479

High

1164308

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1164309

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1164310

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

1164312

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

317851

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

537244

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

818740

CAPG
Macrophage-capping protein

1

0

Small-scale

0.458

High

1164297

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

117208

K7EIH8
DnaJ heat shock protein family

1

4

High-throughput

0.445

High

603286

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.445

High

650184

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.445

High

728273

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.445

High

1103200

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

1164294

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.445

High

1164296

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.445

High

257466

PAGE4
P antigen family member 4

1

2

High-throughput

0.437

High

1164298

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025