Protein: FLT3
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)

Gene: FLT3
Organism: Homo sapiens
Interactions: 201
UniProt ID: P36888

Gene Ontology (top 5):
GO:0001776 - leukocyte homeostasis
GO:0002318 - myeloid progenitor cell differentiation
GO:0002328 - pro-B cell differentiation
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738168

FLT3
Receptor-type tyrosine-protein kinase FLT3

3

17

Small-scale

0.845

High

738172

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.825

High

655242

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.776

High

738197

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.770

High

181810

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.754

High

738170

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.724

High

738203

SLAP1
Src-like-adapter

1

20

Small-scale

0.724

High

382331

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

8

High-throughput

0.691

High

488144

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

8

High-throughput

0.691

High

738204

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.690

High

337376

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.647

High

411619

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.647

High

412062

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.647

High

433274

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.647

High

522826

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

596366

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.647

High

738173

CRK
Adapter molecule crk

1

20

Small-scale

0.647

High

738174

CRKL
Crk-like protein

1

20

Small-scale

0.647

High

738179

BLK
Tyrosine-protein kinase Blk

1

20

Small-scale

0.647

High

383656

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

158416

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

6

Small-scale

0.618

High

414791

CDK1
Cyclin-dependent kinase 1

1

8

High-throughput

0.618

High

433624

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

442785

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

454802

FGR
Tyrosine-protein kinase Fgr

1

20

Small-scale

0.618

High

738192

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

738250

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

7

Small-scale

0.618

High

738259

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.618

High

147491

SOCS6
Suppressor of cytokine signaling 6

1

20

Small-scale

0.579

High

738272

TENS1
Tensin-1

1

12

Small-scale

0.579

High

610268

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.561

High

716828

CTNB1
Catenin beta-1

1

3

Small-scale

0.561

High

146603

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.553

High

738236

PHC2
Polyhomeotic-like protein 2

1

3

High-throughput

0.553

High

738270

LRC40
Leucine-rich repeat-containing protein 40

1

10

High-throughput

0.553

High

161031

CLGN
Calmegin

1

10

High-throughput

0.536

High

654124

CALX
Calnexin

1

10

High-throughput

0.536

High

738200

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.536

High

738273

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.536

High

738214

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.513

High

159025

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

7

Small-scale

0.512

High

738233

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

Small-scale

0.512

High

738306

NEMO
NF-kappa-B essential modulator

1

4

High-throughput

0.512

High

215113

LANC1
Glutathione S-transferase LANCL1

1

2

High-throughput

0.500

High

738244

PO210
Nuclear pore membrane glycoprotein 210

1

1

High-throughput

0.489

High

738269

GHC1
Mitochondrial glutamate carrier 1

1

3

High-throughput

0.489

High

116785

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.479

High

130454

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

5

High-throughput

0.479

High

150182

AP3D1
AP-3 complex subunit delta-1

1

8

High-throughput

0.479

High

150889

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.479

High

208535

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

4

High-throughput

0.479

High

229327

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

7

High-throughput

0.479

High

240535

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

10

High-throughput

0.479

High

311491

SMC2
Structural maintenance of chromosomes protein 2

1

11

High-throughput

0.479

High

322265

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

376434

APOB
Apolipoprotein B-100

1

1

High-throughput

0.479

High

431600

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.479

High

437721

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

10

High-throughput

0.479

High

475426

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

505352

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.479

High

532069

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

3

High-throughput

0.479

High

571682

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

10

High-throughput

0.479

High

574613

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

588551

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.479

High

592635

RAB6A
Ras-related protein Rab-6A

1

7

High-throughput

0.479

High

737252

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

738169

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.479

High

738175

SYQ
Glutamine--tRNA ligase

1

3

High-throughput

0.479

High

738176

EMD
Emerin

1

6

High-throughput

0.479

High

738177

SERPH
Serpin H1

1

6

High-throughput

0.479

High

738181

SYRC
Arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

738182

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

7

High-throughput

0.479

High

738184

SYMC
Methionine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

738186

TMM33
Transmembrane protein 33

1

2

High-throughput

0.479

High

738190

ARF6
ADP-ribosylation factor 6

1

11

High-throughput

0.479

High

738194

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

High-throughput

0.479

High

738199

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

2

High-throughput

0.479

High

738201

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

738202

NDK3
Nucleoside diphosphate kinase 3

1

2

High-throughput

0.479

High

738208

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.479

High

738210

SMC1A
Structural maintenance of chromosomes protein 1A

1

11

High-throughput

0.479

High

738213

SYK
Lysine--tRNA ligase

1

5

High-throughput

0.479

High

738216

PCH2
Pachytene checkpoint protein 2 homolog

1

4

High-throughput

0.479

High

738220

Q4LE69
1-phosphatidylinositol 4-kinase

1

11

High-throughput

0.479

High

738221

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

4

High-throughput

0.479

High

738224

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.479

High

738225

ECM29
Proteasome adapter and scaffold protein ECM29

1

8

High-throughput

0.479

High

738226

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.479

High

738229

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

738230

DHX30
ATP-dependent RNA helicase DHX30

1

7

High-throughput

0.479

High

738235

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.479

High

738241

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.479

High

738242

DDX54
ATP-dependent RNA helicase DDX54

1

14

High-throughput

0.479

High

738246

DNJC9
DnaJ homolog subfamily C member 9

1

19

High-throughput

0.479

High

738254

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

9

High-throughput

0.479

High

738255

DDX27
Probable ATP-dependent RNA helicase DDX27

1

14

High-throughput

0.479

High

738262

PKP2
Plakophilin-2

1

9

High-throughput

0.479

High

738266

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

738267

DDX47
Probable ATP-dependent RNA helicase DDX47

1

9

High-throughput

0.479

High

738268

YTDC2
3'-5' RNA helicase YTHDC2

1

7

High-throughput

0.479

High

738276

HELLS
Lymphoid-specific helicase

1

9

High-throughput

0.479

High

738277

MDN1
Midasin

1

7

High-throughput

0.479

High

738278

DD19A
ATP-dependent RNA helicase DDX19A

1

4

High-throughput

0.479

High

738281

DDX56
Probable ATP-dependent RNA helicase DDX56

1

12

High-throughput

0.479

High

738283

SYLC
Leucine--tRNA ligase, cytoplasmic

1

7

High-throughput

0.479

High

738284

DHCR7
7-dehydrocholesterol reductase

1

2

High-throughput

0.479

High

738286

SEC63
Translocation protein SEC63 homolog

1

13

High-throughput

0.479

High

738289

BAZ1B
Tyrosine-protein kinase BAZ1B

1

9

High-throughput

0.479

High

738292

TTF2
Transcription termination factor 2

1

13

High-throughput

0.479

High

738293

SMC3
Structural maintenance of chromosomes protein 3

1

11

High-throughput

0.479

High

738299

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.479

High

738300

HYOU1
Hypoxia up-regulated protein 1

1

15

High-throughput

0.479

High

738301

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

2

High-throughput

0.479

High

738305

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.479

High

196036

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.458

High

738178

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.458

High

738209

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.458

High

738212

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

738215

PUM3
Pumilio homolog 3

1

0

High-throughput

0.458

High

738219

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

738222

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

738253

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.458

High

738282

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

738295

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.458

High

268413

BAF
Barrier-to-autointegration factor

1

3

High-throughput

0.457

High

127200

IPO5
Importin-5

1

7

High-throughput

0.437

High

201571

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

1

High-throughput

0.437

High

207903

XPOT
Exportin-T

1

10

High-throughput

0.437

High

224332

RAD21
Double-strand-break repair protein rad21 homolog

1

2

High-throughput

0.437

High

230018

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

1

High-throughput

0.437

High

260779

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.437

High

263183

SC22B
Vesicle-trafficking protein SEC22b

1

4

High-throughput

0.437

High

273018

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.437

High

273709

NU155
Nuclear pore complex protein Nup155

1

6

High-throughput

0.437

High

315305

NSA2
Ribosome biogenesis protein NSA2 homolog

1

2

High-throughput

0.437

High

398660

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

4

High-throughput

0.437

High

438707

SRPRA
Signal recognition particle receptor subunit alpha

1

5

High-throughput

0.437

High

451855

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

5

High-throughput

0.437

High

506164

PYGB
Glycogen phosphorylase, brain form

1

3

High-throughput

0.437

High

588847

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

5

High-throughput

0.437

High

738171

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

5

High-throughput

0.437

High

738180

DHB4
Peroxisomal multifunctional enzyme type 2

1

5

High-throughput

0.437

High

738183

PSA
Puromycin-sensitive aminopeptidase

1

1

High-throughput

0.437

High

738185

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.437

High

738188

EPIPL
Epiplakin

1

5

High-throughput

0.437

High

738189

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

4

High-throughput

0.437

High

738191

ERF1
Eukaryotic peptide chain release factor subunit 1

1

3

High-throughput

0.437

High

738193

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.437

High

738195

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.437

High

738198

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

5

High-throughput

0.437

High

738205

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.437

High

738206

PWP1
Periodic tryptophan protein 1 homolog

1

7

High-throughput

0.437

High

738207

FHL3
Four and a half LIM domains protein 3

1

9

High-throughput

0.437

High

738211

CND2
Condensin complex subunit 2

1

3

High-throughput

0.437

High

738217

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.437

High

738223

NU188
Nucleoporin NUP188

1

2

High-throughput

0.437

High

738228

NIPBL
Nipped-B-like protein

1

8

High-throughput

0.437

High

738231

TRM1L
TRMT1-like protein

1

2

High-throughput

0.437

High

738232

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.437

High

738234

PHF6
PHD finger protein 6

1

5

High-throughput

0.437

High

738237

TAF1L
Transcription initiation factor TFIID subunit 1-like

1

4

High-throughput

0.437

High

738238

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.437

High

738239

KRI1
Protein KRI1 homolog

1

7

High-throughput

0.437

High

738243

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.437

High

738245

IPO4
Importin-4

1

7

High-throughput

0.437

High

738247

ELYS
Protein ELYS

1

7

High-throughput

0.437

High

738248

GCN1
Stalled ribosome sensor GCN1

1

8

High-throughput

0.437

High

738249

NU205
Nuclear pore complex protein Nup205

1

7

High-throughput

0.437

High

738251

ARHG2
Rho guanine nucleotide exchange factor 2

1

20

High-throughput

0.437

High

738252

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

High-throughput

0.437

High

738256

ZN512
Zinc finger protein 512

1

3

High-throughput

0.437

High

738257

RBM14
RNA-binding protein 14

1

7

High-throughput

0.437

High

738258

PURB
Transcriptional regulator protein Pur-beta

1

2

High-throughput

0.437

High

738260

STRBP
Spermatid perinuclear RNA-binding protein

1

3

High-throughput

0.437

High

738261

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

High-throughput

0.437

High

738263

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.437

High

738265

GNL3
Guanine nucleotide-binding protein-like 3

1

1

High-throughput

0.437

High

738271

XPO5
Exportin-5

1

10

High-throughput

0.437

High

738274

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.437

High

738275

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

12

High-throughput

0.437

High

738279

FANCI
Fanconi anemia group I protein

1

6

High-throughput

0.437

High

738280

RBM28
RNA-binding protein 28

1

1

High-throughput

0.437

High

738287

IPO11
Importin-11

1

3

High-throughput

0.437

High

738290

MRT4
mRNA turnover protein 4 homolog

1

4

High-throughput

0.437

High

738291

DIM1
Probable dimethyladenosine transferase

1

1

High-throughput

0.437

High

738296

SBDS
Ribosome maturation protein SBDS

1

1

High-throughput

0.437

High

738297

DOP2
Protein dopey-2

1

1

High-throughput

0.437

High

738298

NOC2L
Nucleolar complex protein 2 homolog

1

2

High-throughput

0.437

High

738302

TNPO3
Transportin-3

1

13

High-throughput

0.437

High

738303

SRPRB
Signal recognition particle receptor subunit beta

1

19

High-throughput

0.437

High

738304

SAR1B
Small COPII coat GTPase SAR1B

1

16

High-throughput

0.437

High

738294

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.269

Low

738218

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.261

Low

738187

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.249

Low

738196

EXOSX
Exosome complex component 10

1

0

High-throughput

0.249

Low

738227

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.249

Low

738240

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.249

Low

738264

CG050
Uncharacterized protein C7orf50

1

0

High-throughput

0.249

Low

738285

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.249

Low

738288

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024