Protein: F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

Gene: F264, PFKFB4
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q16877

Gene Ontology (top 5):
GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006000 - fructose metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1164293

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

3

15

Small-scale

0.861

High

591931

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

3

15

High-throughput

0.858

High

257051

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

2

15

Small-scale

0.789

High

990279

1433Z
14-3-3 protein zeta/delta

3

19

High-throughput

0.662

High

729874

1433B
14-3-3 protein beta/alpha

3

19

High-throughput

0.643

High

1164313

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

14

Small-scale

0.618

High

1164317

LLR1
Leucine-rich repeat protein 1

2

3

High-throughput

0.606

High

1164325

CDC23
Cell division cycle protein 23 homolog

2

1

High-throughput

0.606

High

691052

1433T
14-3-3 protein theta

2

19

High-throughput

0.601

High

966371

1433G
14-3-3 protein gamma

2

19

High-throughput

0.601

High

1049333

1433F
14-3-3 protein eta

2

19

High-throughput

0.601

High

1164324

FBXL7
F-box/LRR-repeat protein 7

1

1

Small-scale

0.561

High

1164314

C102B
Coiled-coil domain-containing protein 102B

2

2

High-throughput

0.553

High

971578

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.536

High

891592

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.508

High

520689

RRAS
Ras-related protein R-Ras

1

2

High-throughput

0.489

High

1086604

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.489

High

995064

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

241832

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

1164323

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

272224

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

1164318

DHRS6
Dehydrogenase/reductase SDR family member 6

1

0

Small-scale

0.458

High

1164316

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

Small-scale

0.457

High

1164315

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

1164319

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.437

High

1164320

FBX28
F-box only protein 28

1

0

Small-scale

0.288

High

1164321

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

0

High-throughput

0.279

Low

1164322

GBG12

1

0

High-throughput

0.279

Low

665261

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025