Protein: F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

Gene: F261, PFKFB1
Organism: Homo sapiens
Interactions: 23
UniProt ID: P16118

Gene Ontology (top 5):
GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006000 - fructose metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

591921

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

4

14

Small-scale

0.898

High

591931

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

3

15

High-throughput

0.858

High

591930

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

2

15

High-throughput

0.783

High

591925

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

2

2

High-throughput

0.606

High

591933

PKHG4
Puratrophin-1

2

4

High-throughput

0.606

High

591932

VWC2
Brorin

2

1

High-throughput

0.553

High

591927

HXK4
Hexokinase-4

1

3

Small-scale

0.536

High

591924

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.508

High

421443

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

591922

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.501

High

591923

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

8

Small-scale

0.501

High

591926

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.501

High

591928

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

591929

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

591940

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

591938

PASK
PAS domain-containing serine/threonine-protein kinase

1

8

Small-scale

0.445

High

505689

ZN688
Zinc finger protein 688

2

0

High-throughput

0.316

High

591934

ZN474
Zinc finger protein 474

2

0

High-throughput

0.316

High

591935

ZN276
Zinc finger protein 276

2

0

High-throughput

0.316

High

591936

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

591937

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

591939

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025