Protein: F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

Gene: F262, PFKFB2
Organism: Homo sapiens
Interactions: 55
UniProt ID: O60825

Gene Ontology (top 5):
GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

257050

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

2

15

High-throughput

0.811

High

257051

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

2

15

Small-scale

0.789

High

257035

1433T
14-3-3 protein theta

6

18

Small-scale

0.736

High

257036

1433B
14-3-3 protein beta/alpha

6

18

High-throughput

0.734

High

257042

1433Z
14-3-3 protein zeta/delta

6

18

Small-scale

0.732

High

257040

1433G
14-3-3 protein gamma

5

18

High-throughput

0.716

High

257045

1433F
14-3-3 protein eta

5

18

High-throughput

0.714

High

257041

1433E
14-3-3 protein epsilon

3

5

High-throughput

0.667

High

257029

NSD2
Histone-lysine N-methyltransferase NSD2

1

3

High-throughput

0.536

High

257033

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.536

High

257039

NEK4
Serine/threonine-protein kinase Nek4

1

10

High-throughput

0.536

High

257044

SARNP
SAP domain-containing ribonucleoprotein

1

1

High-throughput

0.536

High

257046

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

2

High-throughput

0.536

High

257059

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.536

High

257061

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.536

High

257068

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.536

High

257074

SRRM2
Serine/arginine repetitive matrix protein 2

1

4

High-throughput

0.536

High

257026

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

257052

FA83B
Protein FAM83B

1

0

High-throughput

0.513

High

257060

DOCK8
Dedicator of cytokinesis protein 8

1

0

High-throughput

0.513

High

257064

RBM15
RNA-binding protein 15

1

0

High-throughput

0.513

High

257067

SH23A
SH2 domain-containing protein 3A

1

5

High-throughput

0.489

High

257038

HXK4
Hexokinase-4

1

3

Small-scale

0.481

High

137876

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

240244

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

257027

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

257028

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.479

High

257030

ESR1
Estrogen receptor

1

4

High-throughput

0.479

High

257031

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

257037

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

257043

H31
Histone H3.1

1

1

High-throughput

0.479

High

257047

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

257049

CUL7
Cullin-7

1

1

High-throughput

0.479

High

257053

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

257054

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.479

High

257056

MOB2
MOB kinase activator 2

1

1

High-throughput

0.479

High

257058

CUL9
Cullin-9

1

2

High-throughput

0.479

High

257062

SNX27
Sorting nexin-27

1

3

High-throughput

0.479

High

257066

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

257069

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

257071

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

257072

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

257048

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

257063

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

257075

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

257032

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

257034

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.445

High

257057

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.445

High

257025

PAGE4
P antigen family member 4

1

2

High-throughput

0.437

High

257055

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

114538

H0YHG0
DnaJ homolog subfamily C member 14

1

3

High-throughput

0.407

High

116749

I3L182
Serine/arginine repetitive matrix 2

1

3

High-throughput

0.407

High

257065

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.279

Low

257070

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.279

Low

257073

PGAP2
Acyltransferase PGAP2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025