HitPredict

Interactor 1: CD53 (P19397)
Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
Gene: CD53

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9862348
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Tetraspanin~Tetraspanin
Common GO terms	GO:0001772 - immunological synapse GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 219 Hs			1 236
+	Hs
		887767 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		583857 CD53_HUMAN (1-219): 5.58e-59: 186: 100.00		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		819445 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		CD151_HUMAN (3-231): 1.89e-54: 176: 25.40
+	Hs
		583861 CD53_HUMAN (1-219): 5.58e-59: 186: 100.00		CD82_HUMAN (4-234): 1.57e-49: 164: 23.11
+	Hs
		279369 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		TSN9_HUMAN (5-233): 7.12e-53: 172: 26.05
+	Hs
		602239 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		905534 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65
+	Hs
		446010 CD63_HUMAN (4-217): 4.29e-53: 172: 26.50		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		583854 CD53_HUMAN (1-219): 5.58e-59: 186: 100.00		CD53_HUMAN (1-234): 4.26e-47: 157: 29.06
+	Hs
		279368 TSN9_HUMAN (1-212): 1.06e-51: 168: 40.52		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		502889 CD53_HUMAN (1-219): 5.58e-59: 186: 100.00		CD37_HUMAN (2-232): 3.4e-44: 151: 20.00
+	Hs
		446012 CD63_HUMAN (4-217): 4.29e-53: 172: 26.50		CD82_HUMAN (4-234): 1.57e-49: 164: 23.11
+	Hs
		209300 TSN6_HUMAN (6-217): 1.39e-54: 176: 22.94		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		326051 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		237713 CD63_HUMAN (4-217): 4.29e-53: 172: 26.50		TSN2_HUMAN (3-234): 1.88e-44: 150: 39.22
+	Hs
		326011 CD63_HUMAN (4-217): 4.29e-53: 172: 26.50		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		237778 CD63_HUMAN (4-217): 4.29e-53: 172: 26.50		TSN3_HUMAN (4-236): 1.19e-43: 149: 18.88
+	Hs
		279367 TSN9_HUMAN (1-212): 1.06e-51: 168: 40.52		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		326141 TSN14_HUMAN (10-211): 1.52e-49: 164: 22.27		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48