HitPredict

Interactor 1: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Interactor 2: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 25416956, 16189514, 25910212, 32296183, 11835509, 31980649, 39358380, 17314099, 18815136, 10602478, 25502805, 31515488, unassigned1304
Identification Methods two hybrid, x-ray crystallography, affinity chromatography technology, cross-linking study, enzymatic study, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid, pull down and 3 others

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Interaction Type direct interaction, association, physical association, phosphorylation reaction, phosphotransfer reaction

The annotation score is based on:

Property Details
Interacting Pfam domains NDK~NDK
Common GO terms GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004536 - DNA nuclease activity
GO:0004550 - nucleoside diphosphate kinase activity
GO:0005524 - ATP binding
and 21 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 152
Hs

1 152
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Last updated: 11Aug2025