Protein: NDKA
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)

Gene: NDKA, NME1
Organism: Homo sapiens
Interactions: 173
UniProt ID: P15531

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004536 - DNA nuclease activity
GO:0004550 - nucleoside diphosphate kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584697

NDKA
Nucleoside diphosphate kinase A

13

16

Small-scale

0.984

High

584704

NDKB
Nucleoside diphosphate kinase B

9

17

Small-scale

0.966

High

584752

NDK3
Nucleoside diphosphate kinase 3

6

17

Small-scale

0.954

High

143796

NDKM
Nucleoside diphosphate kinase, mitochondrial

6

17

High-throughput

0.954

High

180222

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

6

1

High-throughput

0.736

High

248192

NDK8
Putative nucleoside diphosphate kinase

2

17

High-throughput

0.712

High

584791

NTAQ1
Protein N-terminal glutamine amidohydrolase

5

0

High-throughput

0.689

High

584729

FXR2
RNA-binding protein FXR2

3

4

High-throughput

0.672

High

584740

NTF2
Nuclear transport factor 2

2

3

High-throughput

0.606

High

584783

LNX1
E3 ubiquitin-protein ligase LNX

2

2

High-throughput

0.606

High

584824

TNPO3
Transportin-3

2

2

High-throughput

0.606

High

584733

TERF1
Telomeric repeat-binding factor 1

2

1

Small-scale

0.601

High

584823

STRAP
Serine-threonine kinase receptor-associated protein

1

1

Small-scale

0.600

High

584739

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

1

Small-scale

0.595

High

240659

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

371073

MYC
Myc proto-oncogene protein

2

2

Small-scale

0.584

High

584761

Q32Q12
Nucleoside diphosphate kinase

1

16

High-throughput

0.575

High

164519

TNPO2
Transportin-2

1

2

High-throughput

0.573

High

445117

S10A6
Protein S100-A6

2

2

High-throughput

0.571

High

457210

TBB5
Tubulin beta chain

2

6

High-throughput

0.571

High

468031

HS90B
Heat shock protein HSP 90-beta

2

2

High-throughput

0.571

High

532336

CH60
60 kDa heat shock protein, mitochondrial

2

6

High-throughput

0.571

High

534589

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.571

High

536431

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.571

High

552490

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

2

High-throughput

0.571

High

565762

EF2
Elongation factor 2

2

5

High-throughput

0.571

High

584698

DESP
Desmoplakin

2

5

High-throughput

0.571

High

584701

TCPA
T-complex protein 1 subunit alpha

2

4

High-throughput

0.571

High

584706

SYVC
Valine--tRNA ligase

2

3

High-throughput

0.571

High

584707

1433T
14-3-3 protein theta

2

5

High-throughput

0.571

High

584708

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

1

High-throughput

0.571

High

584709

PRDX6
Peroxiredoxin-6

2

4

High-throughput

0.571

High

584715

HSPA9
Stress-70 protein, mitochondrial

2

9

High-throughput

0.571

High

584716

TCPZ
T-complex protein 1 subunit zeta

2

4

High-throughput

0.571

High

584717

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

1

High-throughput

0.571

High

584720

TCPE
T-complex protein 1 subunit epsilon

2

5

High-throughput

0.571

High

584721

FAS
Fatty acid synthase

2

2

High-throughput

0.571

High

584722

TCPG
T-complex protein 1 subunit gamma

2

4

High-throughput

0.571

High

584726

TCPQ
T-complex protein 1 subunit theta

2

7

High-throughput

0.571

High

584727

TCPD
T-complex protein 1 subunit delta

2

4

High-throughput

0.571

High

584743

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.571

High

584744

TCPB
T-complex protein 1 subunit beta

2

5

High-throughput

0.571

High

584750

PRDX1
Peroxiredoxin-1

2

4

High-throughput

0.571

High

584753

TIF1B
Transcription intermediary factor 1-beta

2

1

High-throughput

0.571

High

584764

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

584767

RBP10
Ran-binding protein 10

2

5

High-throughput

0.571

High

584797

TCPH
T-complex protein 1 subunit eta

2

5

High-throughput

0.571

High

584814

GID8
Glucose-induced degradation protein 8 homolog

2

4

High-throughput

0.571

High

584821

RUVB1
RuvB-like 1

2

2

High-throughput

0.571

High

533810

MCF2
Proto-oncogene DBL

1

3

Small-scale

0.562

High

570824

MIF
Macrophage migration inhibitory factor

1

1

Small-scale

0.561

High

584803

NIF3L
NIF3-like protein 1

1

1

High-throughput

0.560

High

169926

AURKA
Aurora kinase A

1

3

Small-scale

0.552

High

431689

ITB1
Integrin beta-1

1

2

Small-scale

0.552

High

584773

PRUN1
Exopolyphosphatase PRUNE1

1

0

Small-scale

0.549

High

352923

AGR2
Anterior gradient protein 2 homolog

2

1

Small-scale

0.549

High

584772

PCLI1
PTB-containing, cubilin and LRP1-interacting protein

1

0

High-throughput

0.549

High

415325

HSPB1
Heat shock protein beta-1

2

0

High-throughput

0.547

High

584731

SYRC
Arginine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.547

High

584747

DSG1
Desmoglein-1

2

0

High-throughput

0.547

High

584728

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

135478

DNM1L
Dynamin-1-like protein

1

5

High-throughput

0.536

High

584776

FOXP4
Forkhead box protein P4

1

1

High-throughput

0.536

High

584819

UBP18
Ubl carboxyl-terminal hydrolase 18

1

1

High-throughput

0.536

High

325204

SOX30
Transcription factor SOX-30

1

0

High-throughput

0.518

High

584808

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.518

High

563129

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

584712

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

584758

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

584782

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

584807

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.513

High

584742

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

Small-scale

0.501

High

584724

DYN2
Dynamin-2

1

5

Small-scale

0.500

High

584799

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.500

High

584710

CCND3
G1/S-specific cyclin-D3

1

1

High-throughput

0.481

High

584713

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

584790

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

High-throughput

0.481

High

584817

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.481

High

124575

EYA2
Protein phosphatase EYA2

1

1

High-throughput

0.479

High

135046

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

176138

PER2
Period circadian protein homolog 2

1

1

Small-scale

0.479

High

293154

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315083

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

323153

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.479

High

400232

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

405756

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

482298

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

521187

ARAF
Serine/threonine-protein kinase A-Raf

1

6

High-throughput

0.479

High

584700

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

584702

EGR1
Early growth response protein 1

1

2

High-throughput

0.479

High

584705

TBG1
Tubulin gamma-1 chain

1

8

High-throughput

0.479

High

584711

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.479

High

584714

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

584719

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

584723

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

584725

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.479

High

584736

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

584738

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

3

High-throughput

0.479

High

584741

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

584745

SET
Protein SET

1

2

Small-scale

0.479

High

584748

DYN1
Dynamin-1

1

5

Small-scale

0.479

High

584749

DUSP2
Dual specificity protein phosphatase 2

1

6

High-throughput

0.479

High

584751

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

3

Small-scale

0.479

High

584754

CUL3
Cullin-3

1

1

High-throughput

0.479

High

584755

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

584756

GOGB1
Golgin subfamily B member 1

1

3

High-throughput

0.479

High

584757

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

584759

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

584760

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

584769

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

584770

ASB18
Ankyrin repeat and SOCS box protein 18

1

1

High-throughput

0.479

High

584774

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

584775

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

584777

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

4

High-throughput

0.479

High

584778

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

584779

DYLT5
Dynein light chain Tctex-type 5

1

2

High-throughput

0.479

High

584781

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

584784

DUS19
Dual specificity protein phosphatase 19

1

6

High-throughput

0.479

High

584785

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

3

High-throughput

0.479

High

584786

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

584787

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.479

High

584789

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

584793

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

584794

RANB9
Ran-binding protein 9

1

5

Small-scale

0.479

High

584795

KCD15
BTB/POZ domain-containing protein KCTD15

1

1

Small-scale

0.479

High

584796

EYA3
Protein phosphatase EYA3

1

1

High-throughput

0.479

High

584800

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.479

High

584801

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

584811

DUS22
Dual specificity protein phosphatase 22

1

6

High-throughput

0.479

High

584813

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

584815

OCAD1
OCIA domain-containing protein 1

1

3

High-throughput

0.479

High

584818

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

584820

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

321426

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.460

High

584812

DD19A
ATP-dependent RNA helicase DDX19A

1

0

High-throughput

0.460

High

125205

LEG9
Galectin-9

1

0

High-throughput

0.458

High

257326

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

332852

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

0

Small-scale

0.458

High

540798

ERG
Transcriptional regulator ERG

1

0

Small-scale

0.458

High

577593

PLAK
Junction plakoglobin

1

0

High-throughput

0.458

High

584699

GATA1
Erythroid transcription factor

1

0

Small-scale

0.458

High

584718

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

584730

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

584732

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

584734

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

584735

RAD
GTP-binding protein RAD

1

0

Small-scale

0.458

High

584737

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

584762

MIDN
Midnolin

1

0

High-throughput

0.458

High

584765

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

584766

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

584788

KAT2A
Histone acetyltransferase KAT2A

1

0

Small-scale

0.458

High

584798

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

584805

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

584810

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

584816

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

409248

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

529003

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

584763

H90B3
Putative heat shock protein HSP 90-beta-3

1

2

High-throughput

0.445

High

584804

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

584806

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

584809

S17A5
Sialin

1

2

High-throughput

0.445

High

217787

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

584746

CO7A1
Collagen alpha-1(VII) chain

1

2

High-throughput

0.437

High

584771

ASXL2
Putative Polycomb group protein ASXL2

1

5

High-throughput

0.437

High

584802

ASXL3
Putative Polycomb group protein ASXL3

1

5

High-throughput

0.437

High

584822

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

584703

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.426

High

584780

SR1IP
Protein SREK1IP1

1

0

High-throughput

0.299

High

584792

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

0

High-throughput

0.298

High

281490

FBX24
F-box only protein 24

1

0

Small-scale

0.292

High

239710

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

584768

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025