Protein: TLX2
T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)

Gene: TLX2
Organism: Homo sapiens
Interactions: 140
UniProt ID: O43763

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001707 - mesoderm formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

213312

PO6F2
POU domain, class 6, transcription factor 2

2

20

High-throughput

0.783

High

129960

MEIS1
Homeobox protein Meis1

1

20

High-throughput

0.698

High

213295

PO2F1
POU domain, class 2, transcription factor 1

1

20

High-throughput

0.698

High

213302

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.618

High

213306

MNX1
Motor neuron and pancreas homeobox protein 1

1

20

High-throughput

0.618

High

213320

SATB1
DNA-binding protein SATB1

1

8

High-throughput

0.618

High

213339

ZFHX3
Zinc finger homeobox protein 3

1

12

High-throughput

0.618

High

213403

SATB2
DNA-binding protein SATB2

1

8

High-throughput

0.618

High

213321

TLE1
Transducin-like enhancer protein 1

2

20

High-throughput

0.614

High

213291

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

213325

1433F
14-3-3 protein eta

1

1

Small-scale

0.561

High

213341

KRA62
Keratin-associated protein 6-2

2

3

High-throughput

0.553

High

157822

IRF6
Interferon regulatory factor 6

1

9

High-throughput

0.541

High

213319

IRF9
Interferon regulatory factor 9

1

9

High-throughput

0.541

High

213361

ZN502
Zinc finger protein 502

1

1

High-throughput

0.541

High

213402

TF2AY
TFIIA-alpha and beta-like factor

1

11

High-throughput

0.541

High

213348

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.536

High

213300

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.518

High

135054

NFIB
Nuclear factor 1 B-type

1

14

High-throughput

0.515

High

213328

NFIA
Nuclear factor 1 A-type

1

19

High-throughput

0.515

High

213301

HNF1B
Hepatocyte nuclear factor 1-beta

1

19

High-throughput

0.501

High

213337

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.501

High

156174

PSA7
Proteasome subunit alpha type-7

1

1

High-throughput

0.500

High

213297

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.500

High

213298

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.500

High

213299

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.500

High

213307

EMD
Emerin

1

3

High-throughput

0.500

High

213309

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.500

High

213324

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.500

High

213329

ILF2
Interleukin enhancer-binding factor 2

1

2

High-throughput

0.500

High

213330

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.500

High

213340

DREB
Drebrin

1

5

High-throughput

0.500

High

213350

PABP2
Polyadenylate-binding protein 2

1

2

High-throughput

0.500

High

213355

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.500

High

213357

LS14A
Protein LSM14 homolog A

1

9

High-throughput

0.500

High

213378

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.500

High

213395

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

3

High-throughput

0.500

High

213411

STRAP
Serine-threonine kinase receptor-associated protein

1

7

High-throughput

0.500

High

213308

RT29
Small ribosomal subunit protein mS29

1

1

High-throughput

0.489

High

213316

RT05
Small ribosomal subunit protein uS5m

1

1

High-throughput

0.489

High

213410

RT23
Small ribosomal subunit protein mS23

1

2

High-throughput

0.489

High

213336

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.479

High

213377

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.479

High

213381

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.479

High

213406

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.479

High

127948

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

3

High-throughput

0.479

High

131679

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

146119

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

152561

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

164166

ZN609
Zinc finger protein 609

1

16

High-throughput

0.479

High

213284

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

7

High-throughput

0.479

High

213285

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

213287

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

High-throughput

0.479

High

213289

WIZ
Protein Wiz

1

9

High-throughput

0.479

High

213290

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

213292

ATX1L
Ataxin-1-like

1

5

High-throughput

0.479

High

213293

SKI
Ski oncogene

1

2

High-throughput

0.479

High

213294

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

213296

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.479

High

213310

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.479

High

213322

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

213323

TLE4
Transducin-like enhancer protein 4

1

20

High-throughput

0.479

High

213326

TLE5
TLE family member 5

1

20

High-throughput

0.479

High

213332

PWP1
Periodic tryptophan protein 1 homolog

1

7

High-throughput

0.479

High

213333

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

15

High-throughput

0.479

High

213342

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

213344

NIPBL
Nipped-B-like protein

1

10

High-throughput

0.479

High

213345

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

12

High-throughput

0.479

High

213346

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

213347

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

213349

PCGF5
Polycomb group RING finger protein 5

1

10

High-throughput

0.479

High

213351

LDB1
LIM domain-binding protein 1

1

4

High-throughput

0.479

High

213352

PB1
Protein polybromo-1

1

8

High-throughput

0.479

High

213353

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

213354

DHX37
Probable ATP-dependent RNA helicase DHX37

1

3

High-throughput

0.479

High

213358

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

213359

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

213360

KDM2B
Lysine-specific demethylase 2B

1

4

High-throughput

0.479

High

213362

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

12

High-throughput

0.479

High

213363

DDX54
ATP-dependent RNA helicase DDX54

1

2

High-throughput

0.479

High

213364

RT27
Small ribosomal subunit protein mS27

1

2

High-throughput

0.479

High

213366

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

213367

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

213370

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

20

High-throughput

0.479

High

213371

ZN512
Zinc finger protein 512

1

5

High-throughput

0.479

High

213372

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

213373

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

213382

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

3

High-throughput

0.479

High

213383

ZN644
Zinc finger protein 644

1

12

High-throughput

0.479

High

213385

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

20

High-throughput

0.479

High

213389

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

213390

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.479

High

213394

DDX56
Probable ATP-dependent RNA helicase DDX56

1

7

High-throughput

0.479

High

213397

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

High-throughput

0.479

High

213398

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

8

High-throughput

0.479

High

213399

TCF20
Transcription factor 20

1

19

High-throughput

0.479

High

213401

PRR12
Proline-rich protein 12

1

17

High-throughput

0.479

High

213407

ZN281
Zinc finger protein 281

1

8

High-throughput

0.479

High

213412

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

213331

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.458

High

213335

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.458

High

213384

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.458

High

213387

MOV10
Helicase MOV-10

1

0

High-throughput

0.458

High

213400

MRT4
mRNA turnover protein 4 homolog

1

0

High-throughput

0.458

High

172939

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.457

High

213303

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.457

High

213391

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.457

High

213288

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.437

High

213304

RBM34
RNA-binding protein 34

1

2

High-throughput

0.437

High

213313

RT22
Small ribosomal subunit protein mS22

1

2

High-throughput

0.437

High

213315

RT35
Small ribosomal subunit protein mS35

1

1

High-throughput

0.437

High

213318

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.437

High

213327

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.437

High

213334

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

213343

RRP12
RRP12-like protein

1

1

High-throughput

0.437

High

213369

DDX27
Probable ATP-dependent RNA helicase DDX27

1

5

High-throughput

0.437

High

213374

DDX50
ATP-dependent RNA helicase DDX50

1

2

High-throughput

0.437

High

213376

PYGO2
Pygopus homolog 2

1

3

High-throughput

0.437

High

213379

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.437

High

213380

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.437

High

213386

FBRS
Probable fibrosin-1

1

9

High-throughput

0.437

High

213388

FBSL
Fibrosin-1-like protein

1

9

High-throughput

0.437

High

213392

DDX18
ATP-dependent RNA helicase DDX18

1

1

High-throughput

0.437

High

213393

RBM28
RNA-binding protein 28

1

1

High-throughput

0.437

High

213396

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.437

High

213404

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.437

High

213405

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.437

High

213408

RRP15
RRP15-like protein

1

1

High-throughput

0.437

High

213413

RT18B
Small ribosomal subunit protein mS40

1

2

High-throughput

0.437

High

213317

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.279

Low

213286

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.249

Low

213305

NOP2
Probable 28S rRNA

1

0

High-throughput

0.249

Low

213311

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.249

Low

213314

RT10
Small ribosomal subunit protein uS10m

1

0

High-throughput

0.249

Low

213338

PUM3
Pumilio homolog 3

1

0

High-throughput

0.249

Low

213356

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.249

Low

213365

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.249

Low

213368

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.249

Low

213375

CG050
Uncharacterized protein C7orf50

1

0

High-throughput

0.249

Low

213409

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024