HitPredict

Interactor 1: HME2 (P19622)
Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2)
Gene: EN2

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 333 Hs			1 770
+	Hs
		724224 MSX2_HUMAN (137-306): 3.78e-48: 164: 28.82		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		829830 HXA1_HUMAN (73-317): 3.54e-33: 126: 21.22		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980587 HME1_HUMAN (55-333): 6.69e-31: 121: 46.36		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Mm
		526710 MSX1_MOUSE (134-306): 1.9e-31: 121: 22.04		TLE4_MOUSE (1-770): 0: 563: 86.27
+	Hs
		980926 HME1_HUMAN (55-333): 6.69e-31: 121: 46.36		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		980732 HME1_HUMAN (55-333): 6.69e-31: 121: 46.36		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		724225 MSX2_HUMAN (137-306): 3.78e-48: 164: 28.82		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Hs
		980675 EMX2_HUMAN (117-333): 1.85e-34: 128: 20.09		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Hs
		980676 HME1_HUMAN (55-333): 6.69e-31: 121: 46.36		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Dm
		367240 HMEN_DROME (161-332): 1.79e-35: 136: 52.60		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Dm
		403512 HMIN_DROME (65-325): 4.48e-33: 130: 35.79		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Dm
		558381 Q7KUL4_DROME (219-329): 6.18e-32: 123: 36.04		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Hs
		724228 MSX2_HUMAN (137-306): 3.78e-48: 164: 28.82		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		829834 HXA1_HUMAN (73-317): 3.54e-33: 126: 21.22		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		447242 HXB5_HUMAN (113-307): 3.13e-33: 125: 26.47		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Mm
		526708 MSX1_MOUSE (134-306): 1.9e-31: 121: 22.04		TLE5_MOUSE (1-200): 1.04e-91: 287: 64.50
+	Hs
		985207 HME1_HUMAN (55-333): 6.69e-31: 121: 46.36		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Ce
		137666 HM16_CAEEL (192-305): 4.92e-39: 138: 56.45		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Hs
		245592 HME1_HUMAN (55-333): 6.69e-31: 121: 46.36		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		447294 HXB5_HUMAN (113-307): 3.13e-33: 125: 26.47		GBB4_HUMAN (686-769): 9.66e-14: 75.2: 18.82