HitPredict

Interactor 1: CXCL3 (P19876)
C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]
Gene: CXCL3

Interactor 2: CXCR2 (P25025)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)
Gene: CXCR2

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8702798
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 360
+	Hs
		587767 CXCL2_HUMAN (1-107): 2.01e-33: 113: 87.85		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		448988 GROA_HUMAN (1-107): 2.59e-31: 108: 86.92		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		364042 CXCL7_HUMAN (25-106): 4.34e-28: 100: 45.12		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		500672 CXCL2_MOUSE (9-107): 3.12e-32: 110: 64.65		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		625748 CXCL5_HUMAN (30-105): 2.87e-26: 95.5: 48.68		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		625758 CXCL6_HUMAN (30-105): 6.17e-25: 92.1: 42.11		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		486185 IL8_HUMAN (30-107): 9.65e-25: 91.3: 37.98		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		522397 GROA_MOUSE (33-103): 1.4e-26: 95.9: 66.20		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		217751 CXL13_HUMAN (31-107): 1.8e-23: 88.2: 23.08		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		364080 PLF4_HUMAN (40-103): 3.07e-21: 82.4: 42.19		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		364105 CXL10_HUMAN (17-102): 3.63e-21: 82: 22.73		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		448987 GROA_HUMAN (1-107): 2.59e-31: 108: 86.92		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		364041 CXCL7_HUMAN (25-106): 4.34e-28: 100: 45.12		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625736 CXCL5_HUMAN (30-105): 2.87e-26: 95.5: 48.68		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625737 CXCL6_HUMAN (30-105): 6.17e-25: 92.1: 42.11		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		486184 IL8_HUMAN (30-107): 9.65e-25: 91.3: 37.98		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		217747 CXL13_HUMAN (31-107): 1.8e-23: 88.2: 23.08		CXCR5_HUMAN (3-360): 2.25e-65: 213: 35.42
+	Hs
		217753 CXL13_HUMAN (31-107): 1.8e-23: 88.2: 23.08		ACKR4_HUMAN (4-358): 2.16e-65: 212: 31.55
+	Mm
		291524 CXL10_MOUSE (14-103): 1.3e-24: 90.9: 22.83		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67
+	Mm
		291525 CXCL9_MOUSE (16-99): 4.11e-24: 90.5: 36.78		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67