HitPredict

Interactor 1: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002102 - podosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0045296 - cadherin binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 550 Hs			1 4684
+	Hs
		1117369 SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12		PLEC_HUMAN (1-4684): 0: 1793: 100.00
+	Hs
		1028767 SRC8_HUMAN (1-550): 0: 561: 100.00		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Rn
		591445 SPTN1_RAT (213-549): 6.28e-34: 139: 14.12		ACTN1_RAT (153-894): 2.1e-116: 396: 24.03
+	Hs
		320206 SRBS2_HUMAN (447-549): 1.7e-11: 69.2: 21.91		ACTN1_HUMAN (153-894): 1.99e-116: 396: 23.90
+	Mm
		1190854 SRBS2_MOUSE (452-549): 1.44e-11: 69.6: 22.00		ACTN1_MOUSE (153-894): 2.79e-115: 393: 24.16
+	Rn
		591442 SPTN1_RAT (213-549): 6.28e-34: 139: 14.12		Q6XD99_RAT (1005-2737): 1.04e-31: 140: 11.13
+	Hs
		1028762 SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		1028863 PACN1_HUMAN (241-549): 2.38e-31: 128: 16.86		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		174755 SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12		SPTN2_HUMAN (1390-3107): 3.29e-22: 108: 12.11
+	Hs
		540251 SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12		SPTB1_HUMAN (1903-3210): 1e-21: 107: 10.84
+	Hs
		1117474 SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12		SPTN4_HUMAN (1380-3073): 2.14e-16: 89.7: 11.41
+	Hs
		1040286 SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		1028778 ITSN1_HUMAN (165-548): 6.15e-15: 80.5: 11.99		SPTB2_HUMAN (1005-2737): 3.24e-30: 135: 9.83
+	Hs
		220736 PPIP1_HUMAN (198-549): 4.06e-33: 132: 15.18		DESP_HUMAN (404-1000): 1.7e-12: 76.9: 9.56
+	Hs
		1040367 PACN1_HUMAN (241-549): 2.38e-31: 128: 16.86		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		587786 SH3G3_HUMAN (365-549): 5.48e-31: 125: 18.82		DESP_HUMAN (404-1000): 1.7e-12: 76.9: 9.56
+	Hs
		1040391 ITSN2_HUMAN (398-548): 1.25e-18: 92.3: 17.88		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90
+	Hs
		1040304 ITSN1_HUMAN (165-548): 6.15e-15: 80.5: 11.99		DYST_HUMAN (3439-3682): 1.46e-13: 80.3: 20.90