HitPredict

Interactor 1: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Interactor 2: ORC1 (Q13415)
Origin recognition complex subunit 1 (Replication control protein 1)
Gene: ORC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781, 31160578, 11931757
Identification Methods	affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 432 Hs			1 861
+	Hs
		943785 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		ORC1_HUMAN (1-861): 0: 754: 100.00
+	Xl
		936141 Q66J45_XENLA (10-432): 1.49e-117: 351: 46.90		P70049_XENLA (1-861): 0: 566: 50.67
+	Hs
		590219 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDC6_HUMAN (341-861): 4.3e-99: 321: 22.38
+	Hs
		538599 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDC6_HUMAN (341-861): 4.3e-99: 321: 22.38
+	Sp
		500275 CG23_SCHPO (2-429): 6.88e-113: 341: 24.94		CDC18_SCHPO (364-860): 6.32e-74: 254: 20.14
+	Sc
		447783 CG22_YEAST (11-432): 2.67e-99: 307: 25.65		CDC6_YEAST (429-834): 2.28e-76: 259: 19.54
+	Sp
		737066 CG22_SCHPO (66-424): 2.93e-99: 304: 27.90		CDC18_SCHPO (364-860): 6.32e-74: 254: 20.14