Protein: DHX40
Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD)

Gene: DHX40
Organism: Homo sapiens
Interactions: 233
UniProt ID: Q8IX18

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005681 - spliceosomal complex
GO:0016887 - ATP hydrolysis activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1311819

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

15

High-throughput

0.737

High

572059

TRI27
Zinc finger protein RFP

2

1

High-throughput

0.694

High

1239621

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

4

7

High-throughput

0.691

High

1311823

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

8

11

Small-scale

0.684

High

1311815

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

3

5

High-throughput

0.650

High

1153189

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

8

High-throughput

0.618

High

160104

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

10

High-throughput

0.618

High

183024

NKRF
NF-kappa-B-repressing factor

1

2

High-throughput

0.618

High

238918

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

14

High-throughput

0.618

High

289607

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

High-throughput

0.618

High

315762

RECQ4
ATP-dependent DNA helicase Q4

1

19

High-throughput

0.618

High

926376

BLM
RecQ-like DNA helicase BLM

1

16

High-throughput

0.618

High

1005472

RBM6
RNA-binding protein 6

1

16

High-throughput

0.618

High

1098253

DDX10
Probable ATP-dependent RNA helicase DDX10

1

10

High-throughput

0.618

High

1128052

DHX8
ATP-dependent RNA helicase DHX8

1

15

High-throughput

0.618

High

1203871

NOM1
Nucleolar MIF4G domain-containing protein 1

1

7

High-throughput

0.618

High

1311243

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

9

High-throughput

0.618

High

1311802

DHX40
Probable ATP-dependent RNA helicase DHX40

1

15

High-throughput

0.618

High

1311813

DDX54
ATP-dependent RNA helicase DDX54

1

10

High-throughput

0.618

High

1311831

DDX27
Probable ATP-dependent RNA helicase DDX27

1

12

High-throughput

0.618

High

1311845

DDX23
Probable ATP-dependent RNA helicase DDX23

1

16

High-throughput

0.618

High

1311850

WDR33
pre-mRNA 3' end processing protein WDR33

1

8

High-throughput

0.618

High

1311855

ZN106
Zinc finger protein 106

1

10

High-throughput

0.618

High

1311859

DHX33
ATP-dependent RNA helicase DHX33

1

14

High-throughput

0.618

High

1311861

DDX31
ATP-dependent DNA helicase DDX31

1

11

High-throughput

0.618

High

1311869

RNC
Ribonuclease 3

1

8

High-throughput

0.618

High

1311883

TFP11
Tuftelin-interacting protein 11

1

8

High-throughput

0.618

High

1311886

DDX41
Probable ATP-dependent RNA helicase DDX41

1

13

High-throughput

0.618

High

1311888

GPTC8
G patch domain-containing protein 8

1

8

High-throughput

0.618

High

1311894

DDX52
Probable ATP-dependent RNA helicase DDX52

1

13

High-throughput

0.618

High

1311870

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

911299

IMA5
Importin subunit alpha-5

3

2

High-throughput

0.593

High

1272773

EPMIP
EPM2A-interacting protein 1

2

1

High-throughput

0.574

High

1311838

NUDC1
NudC domain-containing protein 1

2

7

High-throughput

0.574

High

96714

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.553

High

1243822

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.553

High

1247947

ANR11
Ankyrin repeat domain-containing protein 11

1

1

High-throughput

0.553

High

1254549

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

1311817

DGCR8
Microprocessor complex subunit DGCR8

1

1

High-throughput

0.553

High

1311827

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

3

High-throughput

0.553

High

1311905

TF3C3
General transcription factor 3C polypeptide 3

1

6

High-throughput

0.553

High

239122

ZNRD2
Protein ZNRD2

2

2

High-throughput

0.549

High

889603

CLK2
Dual specificity protein kinase CLK2

1

8

High-throughput

0.536

High

1100880

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.536

High

372516

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.533

High

396467

ESR1
Estrogen receptor

2

16

High-throughput

0.521

High

1311843

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.514

High

273553

DJC13
DnaJ homolog subfamily C member 13

1

5

High-throughput

0.489

High

1042030

LMNB2
Lamin-B2

1

7

High-throughput

0.489

High

1054614

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.489

High

1144064

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.489

High

1311824

TRI52
E3 ubiquitin-protein ligase TRIM52

1

7

High-throughput

0.489

High

1311839

CCNL2
Cyclin-L2

1

2

High-throughput

0.489

High

1311884

RBX2
RING-box protein 2

1

4

High-throughput

0.489

High

1311890

AT7L1
Ataxin-7-like protein 1

1

1

High-throughput

0.489

High

130530

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

229041

AKAP8
A-kinase anchor protein 8

1

2

High-throughput

0.479

High

244377

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

3

High-throughput

0.479

High

290620

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.479

High

291107

UTP20
Small subunit processome component 20 homolog

1

2

High-throughput

0.479

High

325919

UBR5
E3 ubiquitin-protein ligase UBR5

1

7

High-throughput

0.479

High

404204

GCR
Glucocorticoid receptor

1

15

High-throughput

0.479

High

412225

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

462505

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

14

High-throughput

0.479

High

552630

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

3

High-throughput

0.479

High

604694

UBF1
Nucleolar transcription factor 1

1

4

High-throughput

0.479

High

639771

TAF1
Transcription initiation factor TFIID subunit 1

1

14

High-throughput

0.479

High

775186

FUS
RNA-binding protein FUS

1

12

High-throughput

0.479

High

794536

RBMX
RNA-binding motif protein, X chromosome

1

9

High-throughput

0.479

High

799277

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.479

High

841397

RBM34
RNA-binding protein 34

1

9

High-throughput

0.479

High

855127

NOP2
28S rRNA

1

3

High-throughput

0.479

High

869059

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.479

High

888637

YLPM1
YLP motif-containing protein 1

1

3

High-throughput

0.479

High

935553

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.479

High

970750

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

986550

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

995685

ACTC
Actin, alpha cardiac muscle 1

1

4

High-throughput

0.479

High

1004361

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

1043703

CEBPZ
CCAAT/enhancer-binding protein zeta

1

1

High-throughput

0.479

High

1095138

RED
Protein Red

1

2

High-throughput

0.479

High

1109167

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

10

High-throughput

0.479

High

1111093

SNW1
SNW domain-containing protein 1

1

8

High-throughput

0.479

High

1126992

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

1130329

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.479

High

1130776

RRP5
Protein RRP5 homolog

1

16

High-throughput

0.479

High

1130936

BMS1
Ribosome biogenesis protein BMS1 homolog

1

1

High-throughput

0.479

High

1134000

ZN638
Zinc finger protein 638

1

6

High-throughput

0.479

High

1140527

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1148358

KS6A1
Ribosomal protein S6 kinase alpha-1

1

2

High-throughput

0.479

High

1148439

SAFB1
Scaffold attachment factor B1

1

6

High-throughput

0.479

High

1152547

ELAV1
ELAV-like protein 1

1

1

High-throughput

0.479

High

1160201

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

8

High-throughput

0.479

High

1161140

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.479

High

1180457

C19L2
CWF19-like protein 2

1

2

High-throughput

0.479

High

1198594

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.479

High

1206720

RRP12
RRP12-like protein

1

4

High-throughput

0.479

High

1212002

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

8

High-throughput

0.479

High

1212635

RBM20
RNA-binding protein 20

1

5

High-throughput

0.479

High

1229556

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1240240

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

1

High-throughput

0.479

High

1248036

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

1271728

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.479

High

1279860

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

4

High-throughput

0.479

High

1290577

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1311803

RAVR1
Ribonucleoprotein PTB-binding 1

1

6

High-throughput

0.479

High

1311804

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

6

High-throughput

0.479

High

1311807

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

5

High-throughput

0.479

High

1311808

KRI1
Protein KRI1 homolog

1

1

High-throughput

0.479

High

1311810

PPHLN
Periphilin-1

1

1

High-throughput

0.479

High

1311812

WDR36
WD repeat-containing protein 36

1

6

High-throughput

0.479

High

1311814

PNISR
Arginine/serine-rich protein PNISR

1

5

High-throughput

0.479

High

1311816

CATIN
Splicing factor Cactin

1

2

High-throughput

0.479

High

1311818

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

High-throughput

0.479

High

1311822

CELF1
CUGBP Elav-like family member 1

1

4

High-throughput

0.479

High

1311825

FUBP1
Far upstream element-binding protein 1

1

11

High-throughput

0.479

High

1311828

ESS2
Splicing factor ESS-2 homolog

1

2

High-throughput

0.479

High

1311830

RBM33
RNA-binding protein 33

1

4

High-throughput

0.479

High

1311835

YTDC1
YTH domain-containing protein 1

1

2

High-throughput

0.479

High

1311840

RBM15
RNA-binding protein 15

1

5

High-throughput

0.479

High

1311842

CDC5L
Cell division cycle 5-like protein

1

11

High-throughput

0.479

High

1311846

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

2

High-throughput

0.479

High

1311847

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.479

High

1311849

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.479

High

1311851

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

1311852

XRN2
5'-3' exoribonuclease 2

1

4

High-throughput

0.479

High

1311854

NSRP1
Nuclear speckle splicing regulatory protein 1

1

4

High-throughput

0.479

High

1311860

SFR19
Splicing factor, arginine/serine-rich 19

1

11

High-throughput

0.479

High

1311868

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

1311873

RBM28
RNA-binding protein 28

1

6

High-throughput

0.479

High

1311874

SLTM
SAFB-like transcription modulator

1

8

High-throughput

0.479

High

1311875

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

3

High-throughput

0.479

High

1311877

AATF
Protein AATF

1

2

High-throughput

0.479

High

1311879

BCLF1
Bcl-2-associated transcription factor 1

1

8

High-throughput

0.479

High

1311880

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

1311881

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

6

High-throughput

0.479

High

1311882

RBM27
RNA-binding protein 27

1

9

High-throughput

0.479

High

1311887

TASOR
Protein TASOR

1

2

High-throughput

0.479

High

1311889

RALY
RNA-binding protein Raly

1

5

High-throughput

0.479

High

1311892

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

2

High-throughput

0.479

High

1311893

CD11A
Cyclin-dependent kinase 11A

1

6

High-throughput

0.479

High

1311895

TR150
Thyroid hormone receptor-associated protein 3

1

12

High-throughput

0.479

High

1311898

NOC2L
Nucleolar complex protein 2 homolog

1

1

High-throughput

0.479

High

1311902

PAXB1
PAX3- and PAX7-binding protein 1

1

3

High-throughput

0.479

High

1311903

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.479

High

1311805

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.470

High

140604

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

0

High-throughput

0.458

High

1139954

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.458

High

1260515

NOL8
Nucleolar protein 8

1

0

High-throughput

0.458

High

1270299

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.458

High

1311844

NOL10
Nucleolar protein 10

1

0

High-throughput

0.458

High

1311857

ESF1
ESF1 homolog

1

0

High-throughput

0.458

High

1311864

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.458

High

1311900

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.458

High

1311897

FBX7
F-box only protein 7

1

1

High-throughput

0.457

High

430111

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

1209363

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

129241

MEN1
Menin

1

5

High-throughput

0.437

High

215325

TXNL1
Thioredoxin-like protein 1

1

1

High-throughput

0.437

High

242219

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.437

High

244732

ZC3H1
Zinc finger C3H1 domain-containing protein

1

2

High-throughput

0.437

High

256917

H2B1K
Histone H2B type 1-K

1

8

High-throughput

0.437

High

260158

BRD4
Bromodomain-containing protein 4

1

17

High-throughput

0.437

High

272837

PHF2
Lysine-specific demethylase PHF2

1

6

High-throughput

0.437

High

282747

E2F6
Transcription factor E2F6

1

3

High-throughput

0.437

High

319891

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.437

High

321851

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

3

High-throughput

0.437

High

385938

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.437

High

414167

P53
Cellular tumor antigen p53

1

6

High-throughput

0.437

High

589107

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

634513

LMNB1
Lamin-B1

1

7

High-throughput

0.437

High

674234

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.437

High

695891

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

768601

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

776218

SOX6
Transcription factor SOX-6

1

6

High-throughput

0.437

High

799972

COIL
Coilin

1

3

High-throughput

0.437

High

907492

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.437

High

943270

RBM11
Splicing regulator RBM11

1

14

High-throughput

0.437

High

980909

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.437

High

1041833

CENPC
Centromere protein C

1

4

High-throughput

0.437

High

1092864

PRDM2
PR domain zinc finger protein 2

1

1

High-throughput

0.437

High

1095343

RLF
Zinc finger protein Rlf

1

2

High-throughput

0.437

High

1124364

ELOA1
Elongin-A

1

4

High-throughput

0.437

High

1149925

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

1201945

BRDT
Bromodomain testis-specific protein

1

18

High-throughput

0.437

High

1218188

ZN318
Zinc finger protein 318

1

1

High-throughput

0.437

High

1218563

MYSM1
Deubiquitinase MYSM1

1

3

High-throughput

0.437

High

1218930

TASO2
Protein TASOR 2

1

5

High-throughput

0.437

High

1279158

RAI1
Retinoic acid-induced protein 1

1

3

High-throughput

0.437

High

1310080

MGAP
MAX gene-associated protein

1

1

High-throughput

0.437

High

1311806

NIN
Ninein

1

4

High-throughput

0.437

High

1311809

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

1311820

ESR2
Estrogen receptor beta

1

15

High-throughput

0.437

High

1311829

ZBT10
Zinc finger and BTB domain-containing protein 10

1

3

High-throughput

0.437

High

1311833

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

9

High-throughput

0.437

High

1311834

SNX27
Sorting nexin-27

1

1

High-throughput

0.437

High

1311836

TTC14
Tetratricopeptide repeat protein 14

1

6

High-throughput

0.437

High

1311837

LENG8
Leukocyte receptor cluster member 8

1

3

High-throughput

0.437

High

1311848

SETD2
Histone-lysine N-methyltransferase SETD2

1

5

High-throughput

0.437

High

1311853

BRD8
Bromodomain-containing protein 8

1

19

High-throughput

0.437

High

1311856

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

1311862

CLSPN
Claspin

1

2

High-throughput

0.437

High

1311866

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.437

High

1311878

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

3

High-throughput

0.437

High

1311885

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.437

High

1311891

PHF8
Histone lysine demethylase PHF8

1

5

High-throughput

0.437

High

1311901

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

1

High-throughput

0.437

High

1311904

MAFB
Transcription factor MafB

1

8

High-throughput

0.437

High

127130

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.407

High

1311811

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

4

High-throughput

0.407

High

220786

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

0

High-throughput

0.316

High

516900

ECE2
Endothelin-converting enzyme 2

2

0

High-throughput

0.288

High

1254134

CAN12
Calpain-12

1

0

High-throughput

0.279

Low

1311867

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

1311899

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

177469

ZN536
Zinc finger protein 536

1

0

High-throughput

0.249

Low

399993

CATA
Catalase

1

0

High-throughput

0.249

Low

704752

ERCC5
DNA excision repair protein ERCC-5

1

0

High-throughput

0.249

Low

1162410

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1213117

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.249

Low

1244795

FBX38
F-box only protein 38

1

0

High-throughput

0.249

Low

1311821

RREB1
Ras-responsive element-binding protein 1

1

0

High-throughput

0.249

Low

1311826

ARK2N
Protein ARK2N

1

0

High-throughput

0.249

Low

1311832

ZN462
Zinc finger protein 462

1

0

High-throughput

0.249

Low

1311841

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

1311858

ZN644
Zinc finger protein 644

1

0

High-throughput

0.249

Low

1311863

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.249

Low

1311865

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.249

Low

1311871

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.249

Low

1311872

SDA1
Protein SDA1 homolog

1

0

High-throughput

0.249

Low

1311876

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.249

Low

1311896

RRP15
RRP15-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025