HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 28242625, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 821
+	Hs
		591503 H2AX_HUMAN (1-143): 3.73e-74: 219: 100.00		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		591504 H2AX_HUMAN (1-143): 3.73e-74: 219: 100.00		MCM7_HUMAN (22-713): 0: 634: 28.88
+	Hs
		756020 H2A1A_HUMAN (1-125): 8.29e-67: 200: 92.00		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		756032 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		591502 H2AX_HUMAN (1-143): 3.73e-74: 219: 100.00		MCM4_HUMAN (2-736): 0: 632: 27.70
+	Hs
		755975 H2A2B_HUMAN (1-128): 3.45e-66: 198: 92.97		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		755998 H2A1C_HUMAN (1-129): 5.06e-66: 198: 92.25		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		756016 H2A1H_HUMAN (1-128): 2.87e-66: 198: 92.19		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		418856 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		634003 H2A1D_HUMAN (1-129): 1.02e-65: 197: 90.70		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		755970 H2A3_HUMAN (1-129): 5.9e-66: 197: 91.47		MCM5_HUMAN (2-741): 0: 653: 27.42
+	Hs
		591535 H2AX_HUMAN (1-143): 3.73e-74: 219: 100.00		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		418855 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		MCM4_HUMAN (2-736): 0: 632: 27.70
+	Hs
		888264 H2A1A_HUMAN (1-125): 8.29e-67: 200: 92.00		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		888282 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		888174 H2A2B_HUMAN (1-128): 3.45e-66: 198: 92.97		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		888231 H2A1C_HUMAN (1-129): 5.06e-66: 198: 92.25		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		888257 H2A1H_HUMAN (1-128): 2.87e-66: 198: 92.19		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		634008 H2A1D_HUMAN (1-129): 1.02e-65: 197: 90.70		MCM2_HUMAN (22-732): 0: 628: 28.40
+	Hs
		888153 H2A3_HUMAN (1-129): 5.9e-66: 197: 91.47		MCM2_HUMAN (22-732): 0: 628: 28.40