HitPredict

Interactor 1: RAB4A (P20338)
Ras-related protein Rab-4A (EC 3.6.5.2)
Gene: RAB4A

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37232246
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0019003 - GDP binding GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 216
+	Ce
		185001 Q9UAQ6_CAEEL (3-217): 9.72e-87: 256: 41.40		RAN_CAEEL (3-205): 3.44e-97: 283: 88.18
+	Hs
		895084 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19
+	Mm
		895595 RAB8B_MOUSE (6-205): 2.66e-90: 265: 42.00		RAB35_MOUSE (6-188): 1.31e-87: 258: 29.19
+	Hs
		895216 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB1C_HUMAN (7-195): 2.28e-83: 247: 28.13
+	Hs
		895026 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00
+	Hs
		895264 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72
+	Hs
		895217 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB8B_HUMAN (1-204): 5.32e-80: 239: 25.12
+	Mm
		918986 RAB1A_MOUSE (3-218): 3.01e-85: 252: 38.43		RAB35_MOUSE (6-188): 1.31e-87: 258: 29.19
+	Zm
		73944 B4FAE1_MAIZE (6-217): 7.18e-86: 254: 39.15		B4FAE1_MAIZE (4-208): 1.07e-84: 251: 27.89
+	Hs
		1273009 RAB8B_HUMAN (6-205): 1.17e-89: 264: 42.00		RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72
+	Hs
		591801 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00
+	Mm
		877189 RAB8B_MOUSE (6-205): 2.66e-90: 265: 42.00		RAB8A_MOUSE (1-204): 9.08e-80: 239: 24.64
+	Hs
		894787 RAB8B_HUMAN (6-205): 1.17e-89: 264: 42.00		RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76
+	Mm
		880395 RAB4A_MOUSE (1-218): 5.01e-88: 260: 97.71		RAB1B_MOUSE (4-196): 1.67e-80: 240: 28.57
+	Hs
		591800 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Mm
		919000 RAB1A_MOUSE (3-218): 3.01e-85: 252: 38.43		RAB1B_MOUSE (4-196): 1.67e-80: 240: 28.57
+	Hs
		844851 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13
+	Hs
		591794 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57
+	Hs
		591776 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13