Protein: UHRF1
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (mUhrf1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)

Gene: UHRF1
Organism: Mus musculus
Interactions: 25
UniProt ID: Q8VDF2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000792 - heterochromatin
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568899

DNMT1
DNA

6

12

Small-scale

0.941

High

1353939

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

14

Small-scale

0.778

High

1017367

H33
Histone H3.3

2

20

Small-scale

0.727

High

533444

H2B1F
Histone H2B type 1-F/J/L

1

20

Small-scale

0.666

High

1341400

DPPA3
Developmental pluripotency-associated protein 3

2

2

Small-scale

0.619

High

312430

DNM3A
DNA

1

8

Small-scale

0.618

High

1230539

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

Small-scale

0.618

High

1353944

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

10

Small-scale

0.618

High

1353943

Q921K2
Poly [ADP-ribose] polymerase

2

15

Small-scale

0.584

High

1296832

EME1
Structure-specific endonuclease subunit EME1

1

1

Small-scale

0.573

High

1353941

MUS81
Structure-specific endonuclease subunit MUS81

1

1

Small-scale

0.501

High

682155

RBTN2
Rhombotin-2

1

12

Small-scale

0.481

High

688496

TWST1
Twist-related protein 1

1

6

High-throughput

0.479

High

838414

STA5A
Signal transducer and activator of transcription 5A

1

2

Small-scale

0.479

High

1030128

TOP2A
DNA topoisomerase 2-alpha

1

10

Small-scale

0.479

High

1190812

TET1
Methylcytosine dioxygenase TET1

1

1

Small-scale

0.479

High

1224108

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.479

High

1225554

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

12

High-throughput

0.479

High

1225765

TOP2B
DNA topoisomerase 2-beta

1

11

Small-scale

0.479

High

1283152

NANOG
Homeobox protein NANOG

1

13

High-throughput

0.479

High

1353940

RCC1
Regulator of chromosome condensation

1

2

Small-scale

0.479

High

1353942

SP16H
FACT complex subunit SPT16

1

4

Small-scale

0.479

High

87172

H2A1B
Histone H2A type 1-B

1

18

Small-scale

0.436

High

87175

H2A1C
Histone H2A type 1-C

1

18

Small-scale

0.436

High


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Last updated: 11Aug2025