HitPredict

Interactor 1: JUNB (P17275)
Transcription factor JunB (Transcription factor AP-1 subunit JunB)
Gene: JUNB

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	27245101, 28747490
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 347 Hs			1 903
+	Mm
		482137 JUNB_MOUSE (1-347): 1.92e-91: 278: 92.51		ITCH_MOUSE (1-903): 0: 872: 91.16
+	Hs
		430242 JUN_HUMAN (1-347): 5.06e-56: 187: 43.89		ITCH_HUMAN (1-903): 0: 913: 100.00
+	Mm
		432098 JUN_MOUSE (1-347): 8.91e-57: 189: 44.32		ITCH_MOUSE (1-903): 0: 872: 91.16
+	Hs
		429493 JUN_HUMAN (1-347): 5.06e-56: 187: 43.89		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		1156678 NF2L2_HUMAN (8-330): 3.52e-27: 114: 14.71		HACE1_HUMAN (376-897): 1.67e-154: 479: 30.78
+	Hs
		603686 JUNB_HUMAN (1-347): 1.04e-83: 259: 100.00		SMUF1_HUMAN (1-433): 1.57e-45: 177: 16.14
+	Mm
		861874 NF2L2_MOUSE (3-330): 6.32e-41: 153: 16.04		NEDD4_MOUSE (13-424): 1.63e-48: 188: 18.67
+	Hs
		1156704 NF2L2_HUMAN (8-330): 3.52e-27: 114: 14.71		SMUF1_HUMAN (1-433): 1.57e-45: 177: 16.14