HitPredict

Interactor 1: CXA1 (P17302)
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Gene: GJA1

Interactor 2: CXA8 (P48165)
Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)
Gene: GJA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Connexin~Connexin
Common GO terms	GO:0005243 - gap junction channel activity GO:0005886 - plasma membrane GO:0005922 - connexin complex GO:0007267 - cell-cell signaling
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 433
+	Hs
		604297 CXA1_HUMAN (1-382): 0: 540: 100.00		CXA3_HUMAN (1-433): 0: 539: 44.37
+	Hs
		603862 CXA1_HUMAN (1-382): 0: 540: 100.00		CXA5_HUMAN (1-433): 1.71e-163: 466: 43.45
+	Rn
		465074 CXA1_RAT (1-382): 0: 541: 97.64		CXA1_RAT (1-343): 4.8e-123: 364: 39.77
+	Hs
		603825 CXA1_HUMAN (1-382): 0: 540: 100.00		CXA1_HUMAN (1-343): 1.75e-122: 362: 39.48
+	Rn
		465110 CXA1_RAT (1-382): 0: 541: 97.64		CXB2_RAT (3-240): 6.62e-123: 357: 51.46
+	Hs
		603863 CXA1_HUMAN (1-382): 0: 540: 100.00		CXG1_HUMAN (4-366): 1.65e-116: 347: 32.23
+	Mm
		655031 CXA1_MOUSE (1-382): 0: 540: 97.38		CXG1_MOUSE (4-366): 1.58e-114: 342: 31.98
+	Mm
		655032 CXA1_MOUSE (1-382): 0: 540: 97.38		CXB3_MOUSE (3-238): 1.93e-110: 327: 39.92
+	Hs
		604089 CXA1_HUMAN (1-382): 0: 540: 100.00		CXD3_HUMAN (1-238): 4.18e-95: 289: 40.34
+	Hs
		706063 CXA3_HUMAN (1-382): 4.84e-152: 437: 39.59		CXB2_HUMAN (3-240): 5.74e-123: 357: 51.46
+	Hs
		783061 CXA3_HUMAN (1-382): 4.84e-152: 437: 39.59		CXG1_HUMAN (4-366): 1.65e-116: 347: 32.23
+	Hs
		706014 CXA5_HUMAN (1-382): 3.59e-137: 397: 40.40		CXB2_HUMAN (3-240): 5.74e-123: 357: 51.46
+	Hs
		291736 CXA3_HUMAN (1-382): 4.84e-152: 437: 39.59		CXB3_HUMAN (3-238): 4.33e-105: 314: 40.34
+	Hs
		706015 CXA8_HUMAN (1-382): 2.02e-134: 393: 37.36		CXB2_HUMAN (3-240): 5.74e-123: 357: 51.46
+	Hs
		783049 CXG1_HUMAN (4-373): 5.55e-128: 375: 32.49		CXD3_HUMAN (1-238): 4.18e-95: 289: 40.34