HitPredict

Interactor 1: CXB2 (P29033)
Gap junction beta-2 protein (Connexin-26) (Cx26)
Gene: GJB2

Interactor 2: CXA3 (Q9Y6H8)
Gap junction alpha-3 protein (Connexin-46) (Cx46)
Gene: GJA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Connexin~Connexin
Common GO terms	GO:0005243 - gap junction channel activity GO:0005886 - plasma membrane GO:0005922 - connexin complex GO:0007267 - cell-cell signaling GO:1990349 - gap junction-mediated intercellular transport
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 435
+	Hs
		706015 CXB2_HUMAN (1-226): 1.85e-127: 360: 100.00		CXA8_HUMAN (1-435): 0: 563: 44.60
+	Rn
		465110 CXB2_RAT (1-226): 7.12e-127: 359: 93.81		CXA1_RAT (1-352): 6.38e-163: 465: 43.80
+	Hs
		603883 CXA8_HUMAN (2-226): 2.17e-121: 353: 51.46		CXA1_HUMAN (1-352): 9.05e-163: 465: 43.53
+	Hs
		604297 CXA3_HUMAN (2-219): 3.58e-114: 335: 48.26		CXA1_HUMAN (1-352): 9.05e-163: 465: 43.53
+	Hs
		603825 CXA1_HUMAN (2-223): 2.61e-106: 313: 43.75		CXA1_HUMAN (1-352): 9.05e-163: 465: 43.53
+	Hs
		706014 CXB2_HUMAN (1-226): 1.85e-127: 360: 100.00		CXA5_HUMAN (1-435): 3.89e-120: 355: 38.72
+	Hs
		706010 CXB2_HUMAN (1-226): 1.85e-127: 360: 100.00		CXB2_HUMAN (3-237): 3.48e-121: 353: 48.73
+	Hs
		464678 CXB2_HUMAN (1-226): 1.85e-127: 360: 100.00		CXB1_HUMAN (3-242): 3.28e-116: 343: 45.23
+	Mm
		701468 CXB2_MOUSE (1-226): 3.6e-126: 357: 92.92		CXB3_MOUSE (3-236): 5.58e-116: 341: 41.53
+	Hs
		783061 CXA3_HUMAN (2-219): 3.58e-114: 335: 48.26		CXG1_HUMAN (4-380): 3.22e-122: 362: 34.06
+	Mm
		701467 CXB6_MOUSE (1-224): 4.26e-122: 348: 78.13		CXB3_MOUSE (3-236): 5.58e-116: 341: 41.53
+	Hs
		603863 CXA1_HUMAN (2-223): 2.61e-106: 313: 43.75		CXG1_HUMAN (4-380): 3.22e-122: 362: 34.06
+	Mm
		655031 CXA1_MOUSE (2-223): 1.37e-105: 311: 43.33		CXG1_MOUSE (4-258): 2.77e-121: 360: 41.32
+	Hs
		603862 CXA1_HUMAN (2-223): 2.61e-106: 313: 43.75		CXA5_HUMAN (1-435): 3.89e-120: 355: 38.72
+	Hs
		291736 CXA3_HUMAN (2-219): 3.58e-114: 335: 48.26		CXB3_HUMAN (3-242): 7.67e-111: 328: 39.26
+	Hs
		604089 CXA1_HUMAN (2-223): 2.61e-106: 313: 43.75		CXD3_HUMAN (1-233): 4.26e-97: 294: 40.77