HitPredict

Interactor 1: MYD88 (P22366)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Interactor 2: IRF2 (P23906)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	7567467
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0051607 - defense response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 296 Mm			1 349
+	Mm
		547379 MYD88_MOUSE (1-296): 9.14e-132: 377: 100.00		IRF1_MOUSE (1-288): 1.19e-109: 324: 42.91
+	Mm
		621183 TLR3_MOUSE (160-293): 4.74e-36: 139: 20.83		IRF2_MOUSE (1-349): 0: 525: 100.00
+	Hs
		501085 MYD88_HUMAN (15-296): 4.48e-123: 355: 83.69		IRF1_HUMAN (1-265): 3.03e-103: 308: 44.73
+	Mm
		607560 MYD88_MOUSE (1-296): 9.14e-132: 377: 100.00		IRF4_MOUSE (7-146): 1.89e-66: 217: 41.43
+	Hs
		1071068 MYD88_HUMAN (15-296): 4.48e-123: 355: 83.69		IRF4_HUMAN (7-145): 2.95e-63: 209: 41.01
+	Mm
		607537 MYD88_MOUSE (1-296): 9.14e-132: 377: 100.00		IRF5_MOUSE (2-122): 1.9e-52: 182: 40.50
+	Hs
		1039469 MYD88_HUMAN (15-296): 4.48e-123: 355: 83.69		IRF5_HUMAN (2-119): 7.07e-54: 186: 41.53
+	Hs
		1056459 MYD88_HUMAN (15-296): 4.48e-123: 355: 83.69		IRF3_HUMAN (1-146): 4.8e-52: 179: 31.97
+	Mm
		607545 MYD88_MOUSE (1-296): 9.14e-132: 377: 100.00		IRF7_MOUSE (2-213): 2.89e-41: 151: 23.73
+	Hs
		1273344 MYD88_HUMAN (15-296): 4.48e-123: 355: 83.69		IRF7_HUMAN (4-111): 8.65e-39: 145: 32.48
+	Mm
		547405 TLR3_MOUSE (160-293): 4.74e-36: 139: 20.83		IRF1_MOUSE (1-288): 1.19e-109: 324: 42.91
+	Mm
		1145136 TLR4_MOUSE (147-293): 3.19e-45: 165: 23.72		IRF4_MOUSE (7-146): 1.89e-66: 217: 41.43
+	Hs
		120153 TLR4_HUMAN (153-293): 4.24e-46: 167: 25.33		IRF4_HUMAN (7-145): 2.95e-63: 209: 41.01
+	Hs
		120146 TLR4_HUMAN (153-293): 4.24e-46: 167: 25.33		IRF8_HUMAN (7-139): 5.72e-59: 197: 41.48
+	Mm
		618963 IL18R_MOUSE (131-294): 1.07e-46: 165: 21.43		IRF8_MOUSE (7-125): 2.16e-59: 198: 47.06
+	Mm
		619087 TLR4_MOUSE (147-293): 3.19e-45: 165: 23.72		IRF8_MOUSE (7-125): 2.16e-59: 198: 47.06
+	Mm
		618977 TLR13_MOUSE (160-293): 1.02e-42: 158: 24.31		IRF8_MOUSE (7-125): 2.16e-59: 198: 47.06
+	Hs
		237495 TLR2_HUMAN (161-293): 9.64e-45: 163: 23.08		IRF3_HUMAN (1-146): 4.8e-52: 179: 31.97
+	Hs
		886001 TIRAP_HUMAN (106-287): 2.59e-46: 157: 21.31		IRF3_HUMAN (1-146): 4.8e-52: 179: 31.97
+	Hs
		886015 TIRAP_HUMAN (106-287): 2.59e-46: 157: 21.31		IRF7_HUMAN (4-111): 8.65e-39: 145: 32.48