HitPredict - High confidence protein-protein interactions

Interactor 1: ACHB2 (P17787)
Neuronal acetylcholine receptor subunit beta-2
Gene: CHRNB2

Interactor 2: ACHA3 (P32297)
Neuronal acetylcholine receptor subunit alpha-3
Gene: CHRNA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	26801076, 33961781, 8663494
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Neur_chan_LBD~Neur_chan_LBD, Neur_chan_LBD~Neur_chan_memb, Neur_chan_memb~Neur_chan_memb
Common GO terms	GO:0005886 - plasma membrane GO:0005892 - acetylcholine-gated channel complex GO:0006811 - monoatomic ion transport GO:0007165 - signal transduction GO:0007271 - synaptic transmission, cholinergic and 20 others more... GO:0007626 - locomotory behavior GO:0015276 - ligand-gated monoatomic ion channel activity GO:0015464 - acetylcholine receptor activity GO:0016020 - membrane GO:0022848 - acetylcholine-gated monoatomic cation-selective channel activity GO:0034220 - monoatomic ion transmembrane transport GO:0034703 - cation channel complex GO:0035094 - response to nicotine GO:0035095 - behavioral response to nicotine GO:0042166 - acetylcholine binding GO:0043005 - neuron projection GO:0044853 - plasma membrane raft GO:0045202 - synapse GO:0045211 - postsynaptic membrane GO:0048814 - regulation of dendrite morphogenesis GO:0051899 - membrane depolarization GO:0060084 - synaptic transmission involved in micturition GO:0095500 - acetylcholine receptor signaling pathway GO:0098878 - neurotransmitter receptor complex GO:1905144 - response to acetylcholine
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	502
Hs

1	505

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Last updated: 11Aug2025