HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.705

Property	Details
Experiments	32707033, 36931259
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 839
+	Hs
		909605 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		384358 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384604 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384623 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		601493 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	At
		788498 14333_ARATH (3-247): 2.63e-144: 405: 58.30		TMK1_ARATH (1-829): 2.66e-149: 464: 15.94
+	Hs
		683973 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		411316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435554 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		435597 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		926941 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		435604 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	At
		965369 14332_ARATH (3-248): 2.23e-144: 405: 58.47		CLV1_ARATH (23-434): 1.07e-38: 157: 10.69
+	Hs
		169164 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60
+	Hs
		169169 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60
+	At
		788442 14331_ARATH (3-241): 4.5e-144: 405: 56.85		EMS1_ARATH (6-238): 2.63e-23: 108: 12.97
+	At
		788640 14333_ARATH (3-247): 2.63e-144: 405: 58.30		EMS1_ARATH (6-238): 2.63e-23: 108: 12.97
+	At
		186958 14332_ARATH (3-248): 2.23e-144: 405: 58.47		BRI1_ARATH (22-426): 3.77e-18: 92.1: 12.68
+	At
		788683 14333_ARATH (3-247): 2.63e-144: 405: 58.30		BRL2_ARATH (6-173): 1.69e-15: 83.3: 16.67
+	At
		965375 14332_ARATH (3-248): 2.23e-144: 405: 58.47		BRL2_ARATH (6-173): 1.69e-15: 83.3: 16.67