HitPredict

Interactor 1: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	24189400, 12577067
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 217
+	Hs
		924778 MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		516450 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924560 HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		453266 ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		201654 MSI1H_HUMAN (3-341): 3.78e-60: 199: 28.77		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		201698 MSI1H_HUMAN (3-341): 3.78e-60: 199: 28.77		Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37
+	Hs
		454798 ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		433441 MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433940 MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523106 MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522960 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		516342 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Dm
		822855 RB87F_DROME (100-199): 6.5e-21: 94.4: 27.00		SRC42_DROME (131-215): 1.35e-11: 65: 19.54
+	Hs
		454815 ROA3_HUMAN (3-103): 2.78e-17: 84: 33.66		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		411954 ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		412217 RA1L2_HUMAN (3-96): 1.58e-15: 78.2: 31.92		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		453110 ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		523014 RA1L2_HUMAN (3-96): 1.58e-15: 78.2: 31.92		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58