Protein: SC6A4
Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)

Gene: SC6A4, SLC6A4
Organism: Homo sapiens
Interactions: 45
UniProt ID: P31645

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0005178 - integrin binding
GO:0005261 - monoatomic cation channel activity
GO:0005326 - neurotransmitter transmembrane transporter activity
GO:0005335 - serotonin:sodium:chloride symporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

727563

STX1A
Syntaxin-1A

2

15

Small-scale

0.595

High

727552

SYUA
Alpha-synuclein

2

10

Small-scale

0.584

High

727554

VAMP2
Vesicle-associated membrane protein 2

1

3

Small-scale

0.578

High

727557

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

2

Small-scale

0.561

High

727560

GPM6B
Neuronal membrane glycoprotein M6-b

1

1

Small-scale

0.552

High

178912

SCAM2
Secretory carrier-associated membrane protein 2

1

3

Small-scale

0.523

High

697780

CALR
Calreticulin

1

17

Small-scale

0.501

High

536592

HSP7C
Heat shock cognate 71 kDa protein

1

3

Small-scale

0.479

High

727564

DGKD
Diacylglycerol kinase delta

1

7

Small-scale

0.479

High

727568

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

Small-scale

0.479

High

468109

HS90B
Heat shock protein HSP 90-beta

1

0

Small-scale

0.458

High

698424

CALX
Calnexin

1

17

Small-scale

0.457

High

727576

PICK1
PRKCA-binding protein

1

4

Small-scale

0.457

High

184127

RER1
Protein RER1

1

2

High-throughput

0.445

High

184393

SURF4
Surfeit locus protein 4

1

4

High-throughput

0.445

High

609592

LEG3
Galectin-3

1

8

High-throughput

0.445

High

674949

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

High-throughput

0.445

High

690184

STOM
Stomatin

1

5

High-throughput

0.445

High

727555

CAV1
Caveolin-1

1

3

High-throughput

0.445

High

727559

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

High-throughput

0.445

High

727573

CLP1L
Lipid scramblase CLPTM1L

1

7

High-throughput

0.445

High

302694

SYUG
Gamma-synuclein

1

10

Small-scale

0.437

High

727561

TEBP
Prostaglandin E synthase 3

1

2

Small-scale

0.437

High

727578

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.437

High

727566

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.426

High

158404

RFXK
DNA-binding protein RFXANK

1

1

Small-scale

0.407

High

184968

SPTC2
Serine palmitoyltransferase 2

1

4

High-throughput

0.407

High

299617

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

2

High-throughput

0.407

High

727553

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.407

High

727558

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

8

High-throughput

0.407

High

727562

TRAM1
Translocating chain-associated membrane protein 1

1

13

High-throughput

0.407

High

727565

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

12

High-throughput

0.407

High

727567

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

2

High-throughput

0.407

High

727569

RETR3
Reticulophagy regulator 3

1

4

High-throughput

0.407

High

727571

NAT14
Probable N-acetyltransferase 14

1

5

High-throughput

0.407

High

727572

ATLA1
Atlastin-1

1

1

High-throughput

0.407

High

727574

TM109
Voltage-gated monoatomic cation channel TMEM109

1

1

High-throughput

0.407

High

727575

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.407

High

727577

OCAD1
OCIA domain-containing protein 1

1

3

High-throughput

0.407

High

727579

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.407

High

727580

SNX13
Sorting nexin-13

1

12

High-throughput

0.407

High

369626

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.261

Low

727551

STIP1
Stress-induced-phosphoprotein 1

1

0

Small-scale

0.249

Low

727556

DUSP2
Dual specificity protein phosphatase 2

1

0

High-throughput

0.249

Low

727570

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025