HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	9119889, 11157475, 19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0014823 - response to activity GO:0048471 - perinuclear region of cytoplasm GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 1068
+	Mm
		610557 CBL_MOUSE (1-906): 0: 888: 91.59		PK3CA_MOUSE (1-1068): 0: 1317: 98.69
+	Mm
		193567 CBL_MOUSE (1-906): 0: 888: 91.59		PK3CD_MOUSE (1-1064): 0: 1165: 39.37
+	Hs
		610280 CBL_HUMAN (1-906): 0: 917: 100.00		PK3CB_HUMAN (1-1064): 0: 1050: 39.52
+	Mm
		610624 CBL_MOUSE (1-906): 0: 888: 91.59		PK3CB_MOUSE (1-1064): 0: 1070: 38.79
+	Mm
		610648 CBL_MOUSE (1-906): 0: 888: 91.59		PK3CG_MOUSE (1-1062): 0: 938: 32.56
+	Hs
		944242 MDC1_HUMAN (450-878): 1.89e-11: 70.3: 9.33		PRKDC_HUMAN (477-1017): 1.25e-91: 325: 17.90