HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: Q5VWC4 (Q5VWC4)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10)
Gene: PSMD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 380
+	Hs
		97071 E9PMD8_HUMAN (8-294): 0: 508: 95.47		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Hs
		610279 PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Hs
		968730 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		Q5VWC4_HUMAN (1-367): 0: 529: 100.00
+	Hs
		58802 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		PIPSL_HUMAN (3-367): 6.13e-180: 523: 91.78
+	Hs
		933603 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Hs
		968953 PRS8_HUMAN (65-437): 1.52e-124: 369: 44.39		Q5VWC4_HUMAN (1-367): 0: 529: 100.00
+	Hs
		778643 PRS7_HUMAN (21-433): 3.78e-124: 369: 37.35		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Hs
		851347 PRS6B_HUMAN (8-438): 2.68e-121: 361: 37.59		Q5VWC4_HUMAN (1-367): 0: 529: 100.00
+	Hs
		933604 PRS8_HUMAN (65-437): 1.52e-124: 369: 44.39		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Hs
		851276 PRS6B_HUMAN (8-438): 2.68e-121: 361: 37.59		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Xl
		857268 PRS8_XENLA (65-438): 5.1e-122: 364: 44.27		Q4V845_XENLA (1-367): 0: 511: 90.74
+	At
		933563 PRS4A_ARATH (34-433): 6.62e-155: 447: 44.06		PSMD4_ARATH (1-380): 1.05e-137: 399: 41.08
+	Dm
		874957 PRS4_DROME (5-433): 1.77e-133: 392: 42.49		PSMD4_DROME (1-362): 3.93e-148: 426: 58.18
+	Hs
		933590 TERA_HUMAN (167-434): 7.33e-79: 262: 35.09		PSMD4_HUMAN (1-367): 0: 521: 99.18
+	Sp
		152922 PRS6A_SCHPO (26-439): 4.26e-128: 379: 71.57		RPN10_SCHPO (1-242): 9.03e-103: 305: 46.31
+	Sc
		750656 PRS6A_YEAST (26-439): 1.37e-120: 359: 69.05		RPN10_YEAST (1-224): 6.97e-98: 293: 49.15
+	Sc
		806734 PRS4_YEAST (122-431): 4.89e-102: 312: 50.65		RPN10_YEAST (1-224): 6.97e-98: 293: 49.15
+	Sc
		679664 CDC48_YEAST (162-419): 1.21e-81: 270: 37.98		RPN10_YEAST (1-224): 6.97e-98: 293: 49.15