HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	9367879, 35271311, 36931259, 11697890, 9632690, 20618440
Identification Methods	two hybrid, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0043066 - negative regulation of apoptotic process GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 245
+	Hs
		610330 CBL_HUMAN (1-906): 0: 917: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		610234 CBL_HUMAN (1-906): 0: 917: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		610254 CBL_HUMAN (1-906): 0: 917: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Mm
		610575 CBL_MOUSE (1-906): 0: 888: 91.59		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Mm
		610571 CBL_MOUSE (1-906): 0: 888: 91.59		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Mm
		610576 CBL_MOUSE (1-906): 0: 888: 91.59		1433T_MOUSE (1-245): 8.98e-140: 393: 79.18
+	Mm
		610638 CBL_MOUSE (1-906): 0: 888: 91.59		1433B_MOUSE (1-242): 3.77e-128: 364: 87.19
+	Hs
		610327 CBL_HUMAN (1-906): 0: 917: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		610365 CBL_HUMAN (1-906): 0: 917: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		610255 CBL_HUMAN (1-906): 0: 917: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Mm
		610568 CBL_MOUSE (1-906): 0: 888: 91.59		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Mm
		610578 CBL_MOUSE (1-906): 0: 888: 91.59		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07
+	Ce
		1093846 Q6ABG8_CAEEL (43-510): 0: 662: 48.24		14332_CAEEL (3-241): 6.3e-139: 391: 81.59
+	Ce
		1090465 Q19019_CAEEL (49-546): 0: 639: 44.12		14332_CAEEL (3-241): 6.3e-139: 391: 81.59
+	Hs
		297824 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		297821 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		297815 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		647025 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683472 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		904746 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59