Protein: EI2BA
Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)

Gene: EI2BA, EIF2B1
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q14232

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051801

EI2BA
Translation initiation factor eIF2B subunit alpha

5

13

Small-scale

0.918

High

1051849

EI2BG
Translation initiation factor eIF2B subunit gamma

4

14

High-throughput

0.900

High

834410

EI2BB
Translation initiation factor eIF2B subunit beta

4

14

Small-scale

0.895

High

1051853

EI2BD
Translation initiation factor eIF2B subunit delta

3

14

High-throughput

0.861

High

1025629

EI2BE
Translation initiation factor eIF2B subunit epsilon

5

18

Small-scale

0.716

High

1051847

GORS2
Golgi reassembly-stacking protein 2

5

0

High-throughput

0.691

High

1051818

RD3
Protein RD3

4

0

High-throughput

0.668

High

1051834

NTAQ1
Protein N-terminal glutamine amidohydrolase

4

0

High-throughput

0.668

High

686802

GP183
G-protein coupled receptor 183

3

6

High-throughput

0.667

High

793099

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

9

High-throughput

0.667

High

1051836

NECT4
Nectin-4

3

5

High-throughput

0.667

High

1051840

P2RX4
P2X purinoceptor 4

3

2

High-throughput

0.667

High

1051851

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

2

High-throughput

0.667

High

1051856

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.667

High

398705

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

4

Small-scale

0.647

High

409776

GLPB
Glycophorin-B

2

2

High-throughput

0.628

High

1051824

SIGL1
SIGLEC family-like protein 1

2

2

High-throughput

0.628

High

1051820

STX12
Syntaxin-12

3

2

High-throughput

0.609

High

1051860

5MP1
eIF5-mimic protein 1

2

9

Small-scale

0.595

High

227436

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

338424

EGFR
Epidermal growth factor receptor

2

4

Small-scale

0.584

High

1051802

TNIP1
TNFAIP3-interacting protein 1

2

1

High-throughput

0.584

High

1051823

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

0

High-throughput

0.580

High

1051859

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

0

High-throughput

0.580

High

830741

ARL4D
ADP-ribosylation factor-like protein 4D

1

1

High-throughput

0.541

High

429036

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.537

High

133482

NOP56
Nucleolar protein 56

1

2

High-throughput

0.536

High

235857

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.536

High

454699

TACD2
Tumor-associated calcium signal transducer 2

1

2

High-throughput

0.536

High

556506

LEUK
Leukosialin

1

2

High-throughput

0.536

High

583705

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.536

High

626781

PTAFR
Platelet-activating factor receptor

1

8

High-throughput

0.536

High

639583

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

High-throughput

0.536

High

649503

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

714915

BTC
Probetacellulin [Cleaved into: Betacellulin

1

2

High-throughput

0.536

High

780704

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

7

High-throughput

0.536

High

793639

DCC
Netrin receptor DCC

1

2

Small-scale

0.536

High

873840

IF5
Eukaryotic translation initiation factor 5

1

7

High-throughput

0.536

High

896889

ARP2
Actin-related protein 2

1

3

High-throughput

0.536

High

957835

EFNB1
Ephrin-B1

1

4

High-throughput

0.536

High

962078

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1051803

CD226
CD226 antigen

1

6

High-throughput

0.536

High

1051812

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.536

High

1051819

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

2

High-throughput

0.536

High

1051822

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.536

High

1051825

SYT2
Synaptotagmin-2

1

4

High-throughput

0.536

High

1051829

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.536

High

1051838

SEC62
Translocation protein SEC62

1

2

High-throughput

0.536

High

1051854

CC018
Uncharacterized protein C3orf18

1

2

High-throughput

0.536

High

1051857

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.536

High

541007

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

High-throughput

0.515

High

854785

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.515

High

902415

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.513

High

1051827

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.513

High

1051828

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1051833

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.513

High

1051839

SORT
Sortilin

1

0

High-throughput

0.513

High

1051841

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.513

High

574789

ADA2B
Alpha-2B adrenergic receptor

1

2

Small-scale

0.501

High

578809

ADA2C
Alpha-2C adrenergic receptor

1

2

Small-scale

0.501

High

1051843

RM04
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.494

High

724824

MYH9
Myosin-9

1

0

High-throughput

0.493

High

946521

DCD
Dermcidin

1

0

High-throughput

0.493

High

1051804

STK11
Serine/threonine-protein kinase STK11

1

0

Small-scale

0.493

High

452773

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1051844

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

1051858

EXOG
Nuclease EXOG, mitochondrial

1

3

High-throughput

0.489

High

930212

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

47774

RBM47
RNA-binding protein 47

1

1

High-throughput

0.479

High

162736

XPO1
Exportin-1

1

9

High-throughput

0.479

High

294827

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

374224

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

384831

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

617548

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

665236

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

665601

EPHB2
Ephrin type-B receptor 2

1

4

High-throughput

0.479

High

779400

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

872533

EPHB4
Ephrin type-B receptor 4

1

4

High-throughput

0.479

High

909557

1433E
14-3-3 protein epsilon

1

4

Small-scale

0.479

High

959417

VIGLN
Vigilin

1

1

High-throughput

0.479

High

979901

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

4

Small-scale

0.479

High

1035725

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1051809

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1051810

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1051813

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1051832

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1051835

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1051846

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1051852

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1051814

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

310401

EPM2A
Laforin

1

0

Small-scale

0.460

High

453355

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

738209

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.458

High

813460

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1026267

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1051806

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1051831

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1051807

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1051837

CK5P2
CDK5 regulatory subunit-associated protein 2

1

3

High-throughput

0.445

High

244427

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

552710

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

651185

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

720447

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1051817

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1051826

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.437

High

1051830

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1051845

EMRE
Essential MCU regulator, mitochondrial

1

2

High-throughput

0.437

High

1051855

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

401992

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

270867

CLC3A
C-type lectin domain family 3 member A

2

0

High-throughput

0.328

High

1051816

BHA15
Class A basic helix-loop-helix protein 15

2

0

High-throughput

0.328

High

1051821

TRI59
Tripartite motif-containing protein 59

2

0

High-throughput

0.316

High

1051842

CA050
Uncharacterized protein C1orf50

2

0

High-throughput

0.316

High

1051850

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.316

High

1051848

LUC7L
Putative RNA-binding protein Luc7-like 1

2

0

High-throughput

0.298

High

230358

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

383489

PRM2
Protamine-2

1

0

High-throughput

0.279

Low

1051861

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

531828

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.269

Low

1051805

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1051811

FOXR2
Forkhead box protein R2

1

0

High-throughput

0.249

Low

1051815

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1051808

Z385C
Zinc finger protein 385C

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024