HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11894096
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 347
+	Hs
		610495 CBL_HUMAN (1-906): 0: 917: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		610400 CBL_HUMAN (1-906): 0: 917: 100.00		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		610501 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		610437 CBL_HUMAN (1-906): 0: 917: 100.00		Q6ICN0_HUMAN (290-346): 9.74e-12: 65.5: 41.38
+	Hs
		298949 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Mm
		610657 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN2_MOUSE (14-341): 1.76e-12: 70.8: 11.92
+	Mm
		610595 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS2_MOUSE (243-342): 8.22e-12: 68.5: 20.59
+	Mm
		610656 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN1_MOUSE (253-341): 8.49e-12: 68.5: 23.60
+	Mm
		610598 CBL_MOUSE (1-906): 0: 888: 91.59		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Rn
		88774 D3ZV15_RAT (1-883): 0: 833: 89.00		GRB2_RAT (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		82735 B9EKI5_MOUSE (23-901): 0: 799: 47.22		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		1027606 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Mm
		1112081 CBLB_MOUSE (23-901): 0: 791: 45.98		ITSN2_MOUSE (14-341): 1.76e-12: 70.8: 11.92
+	Hs
		1027613 CBLB_HUMAN (23-901): 0: 793: 46.65		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		924539 CBLB_HUMAN (23-901): 0: 793: 46.65		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		298976 CBLB_HUMAN (23-901): 0: 793: 46.65		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Mm
		1112053 CBLB_MOUSE (23-901): 0: 791: 45.98		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Dm
		220607 O46034_DROME (47-460): 0: 746: 70.84		GRAP_DROME (272-339): 1.72e-20: 90.2: 40.85