HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15128873, 12504111, 17548467
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016600 - flotillin complex GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 1292
+	Mm
		610608 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS1_MOUSE (1-1292): 3.51e-71: 263: 20.24
+	Hs
		610393 CBL_HUMAN (1-906): 0: 917: 100.00		SPTN1_HUMAN (304-902): 8.17e-59: 225: 13.39
+	Hs
		557607 CBL_HUMAN (1-906): 0: 917: 100.00		NCK1_HUMAN (708-1005): 1.37e-49: 182: 18.27
+	Hs
		360616 CBL_HUMAN (1-906): 0: 917: 100.00		SPTA1_HUMAN (303-1028): 9.45e-45: 180: 9.89
+	Hs
		208994 CBL_HUMAN (1-906): 0: 917: 100.00		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23
+	Mm
		610633 CBL_MOUSE (1-906): 0: 888: 91.59		NCK1_MOUSE (708-1005): 1.97e-49: 182: 17.63
+	Mm
		434794 CBL_MOUSE (1-906): 0: 888: 91.59		SPTA1_MOUSE (304-899): 7.07e-45: 180: 9.06
+	Mm
		610604 CBL_MOUSE (1-906): 0: 888: 91.59		PLCG1_MOUSE (394-868): 2.19e-42: 171: 12.47
+	Hs
		610379 CBL_HUMAN (1-906): 0: 917: 100.00		MYO1E_HUMAN (1089-1290): 2.99e-25: 116: 16.06
+	Hs
		610400 CBL_HUMAN (1-906): 0: 917: 100.00		SRC8_HUMAN (991-1288): 1.92e-23: 108: 13.38
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (273-858): 7.03e-15: 82.5: 10.91
+	Hs
		298949 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS2_HUMAN (516-926): 8.23e-14: 78.7: 14.74
+	Hs
		47590 CBL_HUMAN (1-906): 0: 917: 100.00		A0A8V8TNS8_HUMAN (766-853): 2.46e-13: 75.7: 28.04
+	Hs
		610517 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN2_HUMAN (1079-1290): 3.39e-12: 73.7: 14.49
+	Mm
		82738 B9EKI5_MOUSE (23-901): 0: 799: 47.22		NCK1_MOUSE (708-1005): 1.97e-49: 182: 17.63
+	Hs
		235473 CBL_HUMAN (1-906): 0: 917: 100.00		VINEX_HUMAN (852-938): 9.3e-09: 61.9: 27.59
+	Mm
		610595 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS2_MOUSE (508-926): 2.95e-15: 83.3: 15.18
+	Mm
		610656 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN1_MOUSE (254-858): 4.49e-15: 82.9: 11.00
+	Mm
		610657 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN2_MOUSE (564-1290): 6.03e-15: 82.5: 11.01
+	Hs
		209046 CBLB_HUMAN (23-901): 0: 793: 46.65		NCK2_HUMAN (767-1019): 1.85e-42: 162: 16.23